Abstract Details

Title Correlations between MRI and Information Processing Speed in MS: Results of a Meta-Analysis

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 115

Objective

Background BACKGROUND: Impaired IPS is common in MS (25-45% of patients). The relationship between whole-brain MRI and IPS (Paced Auditory Serial Addition Test [PASAT], Symbol Digit Modalities Test [SDMT]) measures is systematically examined in this review.

Design/Methods DESIGN/METHODS: Systematic literature searches identified 39 studies published in English through November 2011. Included studies had ?30 MS patients, administered either the SDMT or PASAT, and measured either T2 lesion volume (T2LV) or whole-brain atrophy. A three-pronged analysis was used: (1) meta-analysis of MRI/IPS correlations with near-complete data; (2) analysis of MRI/IPS correlations to rule out publication bias regarding overall significance; and (3) binomial testing to detect trends when comparing strength of correlations of SDMT versus PASAT and T2LV versus atrophy.

Results RESULTS: Studies tended to report only significant correlations between IPS measures and MRI outcomes, suggesting reporting bias. Direct meta-analysis could only be generated for SDMT and T2LV correlations in mixed MS patients (r=-0.54, p<0.001). For the three remaining sets of correlations (SDMT and atrophy, PASAT and T2LV, PASAT and atrophy), Wilkinson's extension of Tippett's procedure found that in most strata and substrata, half or more of the studies had significant results that could not be explained through selective reporting. Binomial tests (p=0.006) favored the SDMT over the PASAT in strength of MRI correlations; in contrast, no differences were observed in the strength of brain-behavior correlations comparing T2LV and atrophy.

Conclusions CONCLUSIONS: A moderate to strong correlation exists between impaired IPS and MRI measures in mixed MS populations. Correlations with MRI measures were stronger for the SDMT than for the PASAT. IPS correlations with T2LV and atrophy were of roughly equal magnitude. Heterogeneity among populations and reporting bias did not appear to be responsible for these findings.

Authors/Disclosures
Stephen M. Rao, PhD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Edward Kim (Novartis Pharmaceuticals Corporation)	No disclosure on file
Kyle Fahrbach	No disclosure on file

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