好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Guillain-Barre Syndrome after West Nile Infection: A Case Report
Infections/AIDS/Prion Disease
P06 - (-)
193
BACKGROUND: In the initial North American outbreak of West Nile Virus infections in the early 2000s, acute flaccid paralysis was initially diagnosed as Guillian-Barre Syndrome, but more recent reports have attributed the acute flaccid paralysis as actually a poliomyelitis like illness. Therefore true cases of Guillian-Barre Syndrome appear rare in comparison with cases of poliomyelitis.
DESIGN/METHODS: This case describes a 20 year old, right-handed, previously healthy male athlete admitted for treatment of ascending weakness and numbness. One month prior he developed a viral syndrome with diffuse headache, macular rash, throat pain, cervical lymphadenopathy, fever, sweats, and chills. Over time he began to have improvement in his constitutional symptoms, but he later developed paresthesias in his fingers and toes and back pain. Symptoms progressed to bilateral ascending lower and upper extremity weakness and bifacial weakness. Exam revealed dysarthric speech, diplopia on rightward gaze, bilateral ptosis, facial diplegia, distal upper and lower extremity weakness, and decreased reflexes.
RESULTS: Diagnostic studies included CSF sutdies showing 3/mm3 white blood cells with 79% lymphocytes and protein of 136 mg/dL. West Nile Virus IgG and IgM were both elevated in the serum and CSF. Plasma exchange treatment was conducted, and patient began to have improvement in his strength and sensation within 2 days. Nerve conduction studies performed after discharge were consistent with a demyelinating polyneuropathy.
CONCLUSIONS: This study concludes that while acute flaccid paralysis is the most common cause of weakness with West Nile Virus, Guillian-Barre syndrome is also a complication of this virus. Correctly diagnosing Guillian-Barre syndrome instead of acute flaccid paralysis following West Nile Virus infection may also be important in deciding proper treatment.
Authors/Disclosures
Wesley D. Reynolds, MD, FAAN (CommonSpirit)
PRESENTER 		Dr. Reynolds has nothing to disclose.
Matthew S. West, MD (University of Colorado) Dr. West has nothing to disclose.
Mario A. Cerdan-Trevino, MD, FAAN (NeuroDoctors) No disclosure on file
Dianna Quan, MD, FAAN (University of Colorado School of Medicine) The institution of Dr. Quan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam. The institution of Dr. Quan has received research support from Alnylam. The institution of Dr. Quan has received research support from Pfizer. The institution of Dr. Quan has received research support from Cytokinetics. The institution of Dr. Quan has received research support from Argenx. The institution of Dr. Quan has received research support from Momenta. The institution of Dr. Quan has received research support from Ionis. The institution of Dr. Quan has received research support from Alexion. The institution of Dr. Quan has received research support from VielaBio. The institution of Dr. Quan has received research support from Apellis. The institution of Dr. Quan has received research support from Avidity. Dr. Quan has received publishing royalties from a publication relating to health care. Dr. Quan has received publishing royalties from a publication relating to health care. Dr. Quan has a non-compensated relationship as a Board Member/President with AANEM that is relevant to AAN interests or activities.
Kenneth L. Tyler, MD, FAAN (University of Colorado School of Medicine) Dr. Tyler has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Protagonist Therapeutics, Newark CA. Dr. Tyler has received personal compensation in the range of $50,000-$99,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Neurological Association/Wiley. Dr. Tyler has received intellectual property interests from a discovery or technology relating to health care. Dr. Tyler has received publishing royalties from a publication relating to health care. Dr. Tyler has a non-compensated relationship as a Director (ex officio) with American Neurological association that is relevant to AAN interests or activities. Dr. Tyler has a non-compensated relationship as a Director with International Society for Neurovirology that is relevant to AAN interests or activities.
No disclosure on file