Abstract Details

Title Mindfulness Based Training in Parkinson's Disease Leads to Increases in Grey Matter Density

Topic Movement Disorders

Presentation(s) P06 - (-)

Poster/Presentation
Number 083

Objective

Background BACKGROUND: Parkinson's disease (PD) is a complex chronic, progressive neurodegenerative syndrome consisting of motor and non-motor symptoms. Up to half of individuals with PD have mild cognitive impairments in the absence of dementia. In a pilot study, we observed that PD patients could benefit from a Mindfulness based intervention (MBI), interpreted on the basis of self-reported measures.

Design/Methods DESIGN/METHODS: A total of 31 PD patients were recruited into a randomized controlled trial comparing MBI consisting of a structured 8-week program of mindfulness training (n = 14) with usual care (UC) (n = 13). 3D T1 weighted (1x1x1 mm3 resolution, Siemens 3T system) MRI data sets were obtained in 27 PD patients, at baseline and after 12 weeks follow-up. Voxel based analysis was performed using DARTEL from the SPM8 software. After image registration, the segmented grey matter images of the baseline were subtracted from the follow-up scan. The resulting difference maps of the MBI and UC group were statistically compared, to examine grey matter density differences in time between both groups. Results were reported at p<0.001, uncorrected for multiple comparisons.

Results RESULTS: An increased grey matter density was found in the MBI group compared to the UC group over time in the right caudate, left and right hippocampus and right amygdala. On the other hand, increased grey matter differences were found in the UC compared to the MBI group in the left cerebellum.

Conclusions CONCLUSIONS: Increased grey matter density was found in the MBI group in regions that have been postulated to play an important role in mediating benefits of meditation. To the best of our knowledge this is the first quantitative analysis of a mindfulness based intervention in PD.

Authors/Disclosures
PRESENTER	No disclosure on file
Wim Van Hecke, PhD (University Hospital Brussels)	Dr. Van Hecke has received personal compensation for serving as an employee of icometrix.
	No disclosure on file
Phyllis C. Zee, MD, PhD (Northwestern Univ Medical School)	Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Apnimed. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CVS Caremark. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Harmony. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Harmony Biosciences. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals Inc.. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Apnimed. Dr. Zee has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for World Sleep Society. Dr. Zee has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for American Brain Foundation. An immediate family member of Dr. Zee has stock in Teva. An immediate family member of Dr. Zee has stock in Pfizer. The institution of Dr. Zee has received research support from National Institutes of Health. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received publishing royalties from a publication relating to health care.
	No disclosure on file
Patrick Cras, MD, PhD (University of Antwerp)	The institution of Dr. Cras has received research support from Belgian Fund for Scientific Research. Dr. Cras has received personal compensation in the range of $0-$499 for serving as a member with National Bioethics Committee.

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