Abstract Details

Title Hemodynamic Response Function Variability in Patients with Aphasia

Topic Behavioral Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 066

Objective

Background BACKGROUND: Although fMRI is increasingly used to assess language-related brain activation in patients with aphasia, few studies have investigated abnormal hemodynamic function in perilesional, remote, contralesional, and atrophic regions, and whether factors such as lesion size and severity of aphasia are associated with hemodynamic abnormalities.

Design/Methods DESIGN/METHODS: Five patients with stroke-induced aphasia, three patients with PPA, and five healthy controls participated in the study. Western Aphasia Battery (WAB) aphasia quotient ranged from 29.3 to 96.3 for the post-stroke patients and from 78.2 to 97.5 for PPA patients. Structural damage was quantified with T1-weighted MR images. Functional MR imaging was performed with an event-related design using an overt picture naming task and a 30-second inter-trial interval to allow quantification of the HRF.

Results RESULTS: Three out of five post-stroke aphasic patients showed significantly abnormal HRFs in perilesional language regions. The three patients with abnormal HRFs had the lowest WAB scores and all had large lesions, whereas the two post-stroke patients with normal HRFs had smaller lesions. In all three PPA patients, HRFs were normal, and atrophy was mild to moderate.

Conclusions CONCLUSIONS: Our results indicate that abnormal task-related HRFs are found in some but not all chronic post-stroke patients with aphasia. In our small series, abnormal HRFs were associated with larger lesion sizes and more severe aphasia. Future studies of larger case series will be necessary to confirm these findings and determine what other factors may be predictive of hemodynamic abnormalities. The three PPA patients did not show any significant changes in HRF. Because these patients were not severely aphasic and had mild to moderate atrophy, it remains possible that hemodynamic abnormalities may occur later in the course of disease.

Authors/Disclosures
Borna Bonakdarpour, MD, FAAN (Mesulam Center for Cognitive Neurology and Alzheimer Disease) PRESENTER	Dr. Bonakdarpour has nothing to disclose.
Steven Z. Rapcsak, MD	Dr. Rapcsak has nothing to disclose.
Timm Oberwahrenbrock, PhD	No disclosure on file
Andrew T. DeMarco, PhD, CCC-SLP (Georgetown University)	Dr. DeMarco has nothing to disclose.
	No disclosure on file
	No disclosure on file

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