Abstract Details

Title Eye Movement Perimetry: Evaluation of Saccadic Latency, Saccadic Amplitude, and Visual Threshold to Peripheral Visual Stimuli in Young Compared with Older Adults

Topic Neuro-ophthalmology/Neuro-otology

Presentation(s) P06 - (-)

Poster/Presentation
Number 005

Objective

Background BACKGROUND: Previous studies have evaluated for age-related differences in saccadic latency and amplitude to peripheral visual stimuli, but have not evaluated for differences using stimuli close to visual threshold. Several studies have suggested that eye movements could be used to evaluate for visual field loss, but have not evaluated the relationship between saccadic latency, amplitude, and visual threshold.

Design/Methods DESIGN/METHODS: We tested 20 normal subjects aged 18-30 years old ("young") and 21 normal subjects at least 60 years old ("older") for detection of briefly-flashed peripheral visual stimuli of differing sizes in 8 locations along the horizontal meridian (±4[deg], ±12[deg], ±20[deg], and ±28[deg]). With the left eye occluded, subjects were instructed to look toward the stimulus. Right eye movements were recorded with an EyeLink 1000 infrared camera. Limiting our analysis to the stimuli in the nasal hemifield (-4[deg], -12[deg], -20[deg], and -28[deg]), we evaluated for group-level differences in saccadic latency, amplitude, and visual threshold for each stimulus position.

Results RESULTS: Saccadic latency increased as stimulus size approached visual threshold in both groups. Older subjects had increased saccadic latencies, decreased saccadic amplitudes, and higher visual thresholds. Repeated-measures ANOVA on ranks demonstrated significant differences (p < 0.05) between the groups in saccadic latency (at all positions), amplitude (at all positions), and visual threshold (at -12[deg], -20[deg], and -28[deg]). In both groups, saccadic latency and visual threshold were positively correlated, whereas amplitude was negatively correlated with saccadic latency and visual threshold.

Conclusions CONCLUSIONS: Older adults have increased latency and decreased amplitude of saccades, as well as higher visual thresholds, to peripheral visual stimuli compared with younger adults. Saccadic latency and amplitude are correlated with visual threshold.

Authors/Disclosures
Matthew J. Thurtell, MD (University of Iowa) PRESENTER	Dr. Thurtell has received publishing royalties from a publication relating to health care.
Gavin Giovannoni, MD (QMUL)	Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Merck KGaA. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche-Genentech. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Moderna. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sandoz. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Astoria Biologica. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zenas. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Medscape.
	No disclosure on file
	No disclosure on file
Michael Wall, MD, FAAN	No disclosure on file

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