Abstract Details

Title Network Analysis of Intrinsic Functional Connectivity in the Semantic Variant of Primary Progressive Aphasia

Topic Behavioral Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 068

Objective

Background BACKGROUND: SV, in which there is progressive deterioration of semantic knowledge, is associated with focal, typically asymmetric, temporal lobe degeneration. However, language abilities must arise from the activity of distributed neural networks. Graph theoretical analysis allows examining the topology of complex network systems.

Design/Methods DESIGN/METHODS: Graph theoretical analysis was applied to resting state (RS) functional magnetic resonance imaging (fMRI) data from 13 SV patients and 25 age- and sex-matched healthy subjects. Functional connectivity between 90 cortical and subcortical brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs.

Results RESULTS: Functional brain networks in SV patients showed loss of small world properties, characterized by a significantly lower clustering coefficient, lower global efficiency and longer characteristic path length compared with healthy elderly subjects. Compared with controls, SV patients did not show hub regions in the left temporal pole, anterior cingulate cortex (ACC), basal ganglia, occipital cortices, and bilateral parietal cortices. Nodal degree and local efficiency were globally reduced in patients relative to controls. SV patients showed the greatest decrease in nodal centrality in the bilateral temporal pole and gyri, amygdala, basal ganglia, orbitofrontal, middle frontal, inferior parietal gyri, occipital cortices, and left fusiform, hippocampus, ACC, postcentral gyrus.

Conclusions CONCLUSIONS: Graph analysis showed that SV functional networks are characterized by an imbalanced structure, with a loss of efficiency in information exchange between both close and distant brain areas. Our study showed that local functional network organization is also altered in SV patients. Focal degeneration of "classic" (temporal) language regions in SV patients may ultimately manifest in widespread connectivity disturbances elsewhere in the brain.

Authors/Disclosures
Federica Agosta (San Raffaele Scientific Institute) PRESENTER	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
	No disclosure on file
	No disclosure on file
Paola Valsasina	Paola Valsasina has nothing to disclose.
	No disclosure on file
Stefano F. Cappa, MD	Dr. Cappa has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elservier. The institution of Dr. Cappa has received research support from Italian Minsitry of Health.
Giuseppe Magnani	Giuseppe Magnani has nothing to disclose.
Massimo Franceschi, MD	No disclosure on file
Andrea Falini	No disclosure on file
Kenneth L. Tyler, MD, FAAN (University of Colorado School of Medicine)	Dr. Tyler has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Protagonist Therapeutics, Newark CA. Dr. Tyler has received personal compensation in the range of $50,000-$99,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Neurological Association/Wiley. Dr. Tyler has received intellectual property interests from a discovery or technology relating to health care. Dr. Tyler has received publishing royalties from a publication relating to health care. Dr. Tyler has a non-compensated relationship as a Director (ex officio) with American Neurological association that is relevant to AAN interests or activities. Dr. Tyler has a non-compensated relationship as a Director with International Society for Neurovirology that is relevant to AAN interests or activities.
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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