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Abstract Details

Resting State Functional Connectivity Alterations of the Sensorimotor and Extra-Motor Networks in Primary Lateral Sclerosis
Anterior Horn
P06 - (-)
138
BACKGROUND: RS fMRI has the potential to provide an in vivo assessment of the motor and extra-motor brain alterations in PLS.
DESIGN/METHODS: RS functional MRI and diffusion tensor (DT) MRI were obtained from 24 PLS patients and 26 healthy controls. Clinical and neuropsychological data were available. RS fMRI data were analyzed using a model free (MELODIC) approach in FSL. Multiple regression models were performed to assess the association between RS connectivity, clinical variables and WM tract fractional anisotropy values.
RESULTS: Compared with controls, PLS patients showed an increased connectivity in the bilateral precentral gyrus of the sensorimotor network, bilateral superior frontal and supramarginal gyri of the fronto-parietal networks, and anterior cingulate cortex (ACC) of the executive network. In PLS, the enhanced sensorimotor connectivity was associated with more severe disability, more rapid rate of progression, and WM damage to the corticospinal tracts and corpus callosum. The increased connectivity of the fronto-parietal networks was related with worse executive/language performances and WM damage to the superior longitudinal fasciculi. Conversely, the enhanced connectivity of the ACC in the executive network correlated with a better performance at a frontal cognitive test and WM integrity of the genu of the corpus callosum.
CONCLUSIONS: Cerebral network breakdown in PLS is characterized by functional connectivity increases. The observation that PLS patients with more severe disability, cognitive impairment and WM damage had the greatest sensorimotor and fronto-parietal functional connectivity lends support to a pathogenic loss of local inhibitory circuitry, rather than only compensatory recruitment.
Authors/Disclosures
Federica Agosta (San Raffaele Scientific Institute)
PRESENTER 		Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Elisa Canu (Ospedale San Raffaele) The institution of Elisa Canu has received research support from Italian Ministry of Health .
No disclosure on file
No disclosure on file
Adriano Chio, MD, FAAN (Dept. of Neuroscience, University of Turin) Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corcept.
Stefano Messina, MD (Istituto Auxologico Italiano, Ospedale San Lu) No disclosure on file
Sandro Iannaccone No disclosure on file
Andrea Calvo, MD, PhD, FAAN (Dept. of Neuroscience, University of Turin) Dr. Calvo has nothing to disclose.
Vincenzo Silani, MD, FAAN (University of Milan Medical School - IRCCS Istituto Auxologico Italiano) Dr. Silani has nothing to disclose.
Andrea Falini No disclosure on file
Giancarlo Comi, MD (University Vita-Salute) Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Teri Schreiner, MD, MPH, FAAN (University of Colorado/ Children's Hospital of Colorado) The institution of Dr. Schreiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CDC. Dr. Schreiner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. The institution of Dr. Schreiner has received research support from Roche Genentech.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.