Abstract Details

Title Cognitive Performance and Brain Integrity in Multiple Sclerosis: A Diffusion Tensor Imaging Study

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 112

Objective

Background BACKGROUND: Disconnection of white matter (WM) tracts and grey matter (GM) damage could be implicated in cognitive dysfunction in MS.

Design/Methods DESIGN/METHODS: We included 67 MS patients and 37 controls. Cognition was evaluated in patients by the Rao battery (normalizing through z-scores). The MRI included structural T1-MPRAGE and diffusion tensor imaging (DTI). Tract-based spatial statistics (TBSS) and voxel-based analysis (VBA) were used to compare DTI values between patients and controls and to localize regions where DTI fractional anisotropy (FA) or mean diffusivity (MD) levels correlated with cognitive z-scores in normal-appearing WM (NAWM) and GM in MS. We correlated z-scores with lesion likelihood through lesion probability mapping (LPM).

Results RESULTS: MS patients showed widespread reduced NAWM FA and increased GM MD in several regions. Verbal memory correlated with specific tracts and regions for each subtest in MS patients: the selective reminding test (SRT) long-term storage correlated with FA in corpus callosum (CC), corona radiata, posterior thalamic radiaton, sagittal stratrum and cingulated gyrus and with GM MD in left angular, occipital, lingual, fusiform and temporal cortex. SRT long-term retrieval displayed similar findings in NAWM, while correlation with GM MD was more extensive (i.e.hippocampus, left insula, angular, occipital and temporal cortex). SRT delayed recall (DR) correlated with FA in CC and with MD in left calcarine, lingual, hippocampus, thalamus and fusiform cortex. Visual memory DR correlated with FA in CC and posterior thalamic radiations. The Symbol Digit Modalities Test showed widespread correlation with NAWM FA. LPM showed periventricular and corona radiata areas correlating with SRT long-term storage and DR.

Conclusions CONCLUSIONS: Both GM and WM microstructure have an influence on cognition that differs in different domains. We provide anatomic rendition of pathways implicated in the different processes of declarative verbal memory.

Authors/Disclosures
Sara Llufriu PRESENTER	Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merci. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbot. Sara Llufriu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi.
	No disclosure on file
Cuellar Gabilondo	No disclosure on file
Jacqueline Palace (John Radcliff Hospital Oxford Univeristy Hospitals Trust)	Dr. Palace has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Merck Serono, Medimmune, Argenx, Janssen, AMgen, UCB, Roche, Novartis, Amplo, Alexion, . Dr. Palace has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx, Sanofi. Dr. Palace has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Roche, UCB, Alexion, Amgen. Dr. Palace has or had stock in Astra Zenica. The institution of Dr. Palace has received research support from Roche, AMPLO, Alexion, UCB,. argenx, amgen. Dr. Palace has received intellectual property interests from a discovery or technology relating to health care.
Yolanda Blanco Morgado, MD	Dr. Blanco Morgado has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Pablo Villoslada, MD, PhD, FAAN (Hospital del Mar Research Institute)	Dr. Villoslada has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Oculis. Dr. Villoslada has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Bionure. Dr. Villoslada has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Telara Therapeutics. Dr. Villoslada has or had stock in Attune Neurosciences.Dr. Villoslada has or had stock in Bionure Therapeutics.Dr. Villoslada has or had stock in Spiral Therapeutics.Dr. Villoslada has or had stock in Adhera Health.Dr. Villoslada has or had stock in Clarity technologies.Dr. Villoslada has or had stock in QMENTA Inc. The institution of Dr. Villoslada has received research support from Start2Cure Foundation. The institution of Dr. Villoslada has received research support from European Commission. The institution of Dr. Villoslada has received research support from Instituto Salud Carlos III. The institution of Dr. Villoslada has received research support from Focused Ultrasound Foundation and ALS Foundation. The institution of Dr. Villoslada has received research support from Caixa Foundation. Dr. Villoslada has received intellectual property interests from a discovery or technology relating to health care.
Francesc R. Graus, MD (IDIBAPS)	Dr. Graus has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MedLink. Dr. Graus has received intellectual property interests from a discovery or technology relating to health care.
Albert Saiz (Hospital Clinico De Barcelona)	Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon Therapeutics. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janseen. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for novartis. Albert Saiz has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen.

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