好色先生

好色先生

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Abstract Details

Low 好色先生 Is Related to Cortical Thinning in 1180 Normal Subjects: Cognitive Battering Hypothesis vs. Cognitive Reserve Hypothesis
Aging and Dementia
P06 - (-)
039
BACKGROUND: In this study, we aimed to test two hypotheses - cognitive reserve vs cognitive battering - used to explain the relationship between education and AD. Given that the cognitive reserve hypothesis might be true, low education would be correlated with cortical thinning regardless of controlling vascular risk factors. On the other hand, according to cognitive battering hypothesis, after controlling vascular risk factors, the correlation would disappear. Therefore our study was designed to find out the relationship between education and cortical thickness before and after controlling risk factors.
DESIGN/METHODS: This study was designed as cross-sectional study. We recruited 1180 subjects at health promotion center of Samsung Medical Center who had normal cognition. We inquired in detail about their formal education and confirmed the history of education information with their caregivers. Cortical thickness was measured using surface based method. In Model1, multiple linear regression was performed after controlling for age, sex and intracranial volume (ICV). In Model 2, we added vascular risk factors such as history of hypertension, diabetes mellitus, hyperlipidemia, body mass index, and ischemic heart disease to independent variable.
RESULTS: In Model 1, low education was associated with cortical thinning in the frontal (p value =0.012) and parietal (p value=0.043) lobe. In Model 2, these statistical significance remained frontal (p value =0.022) and parietal lobe (p value =0.020).
CONCLUSIONS: Our findings suggest that high education has protective effects on the cortical thinning through cognitive reserve theory rather than cognitive battering theory.
Authors/Disclosures
Jun Pyo Kim (Samsung Seoul Hospital)
PRESENTER 		No disclosure on file
Sangwon Seo, MD No disclosure on file
Duk L. Na, MD (Samsung Medical Center) No disclosure on file
Maria Pia Sormani (University of Genoa) Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol meyer. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Immunic. Maria Pia Sormani has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis, Roche. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Maria Pia Sormani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche.