Abstract Details

Title High hs-CRP Levels Are Associated to Histological Vulnerability in Carotid Plaques

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 265

Objective

Background BACKGROUND: Basic and clinical research provides evidence that inflammatory mechanisms play a central role in the pathogenesis and progression of atherosclerosis in the coronary arteries. Little is known about the effect of serum inflammatory markers in the plaque morphology in carotid circulation.

Design/Methods DESIGN/METHODS: Data regarding Carotid plaques was collected from symptomatic patients with more than 70% of carotid stenosis who underwent endarterectomy. In all cases carotid plaques were removed intact and processed for histological examination. Demographic data, vascular risk factor profile and hs-CRP were evaluated in all patients.

Results RESULTS: 59 patients were included; mean age was 70± 8 years. From the total number of patients thirty-six patients (61%) had vulnerable carotid plaques in the histological examination. We found,that Mean hs-CRP plasma level was 12.5±15 mg/L in patients with complex plaques (types IV-VI) according AHA classification vs 4.1±4 mg/L in patients with fibrotic or calcified plaques (p 0.01).

Conclusions CONCLUSIONS: Our data suggests that high hs-CRP plasma level is strongly associated with core necrosis, hemorrhage and with the generation of thrombus in the carotid plaques of those symptomatic patients .We also asumme that it could be a marker of plaque vulnerability.

Authors/Disclosures
Maria C. Zurru, MD PRESENTER	No disclosure on file
	No disclosure on file
Ying Wu	No disclosure on file
	No disclosure on file
Gabriela Orzuza	No disclosure on file
Verena Ramirez Campos, MD (Teva)	Dr. Ramirez Campos has received personal compensation for serving as an employee of teva.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Edgardo Cristiano, MD (Hospital Italiano De Buenos Aires)	Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.

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