Abstract Details

Title Contribution of Intracranial Large Vessel Stenosis and Small Vessel Ischemia to Post-Stroke Cognitive Impairment in an Asian Population

Topic Behavioral Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 063

Objective

Background BACKGROUND: Cerebrovascular disease has been shown to considerably increase the risk of dementia. Several studies have identified demographic, vascular and stroke-related factors associated with post stroke dementia. However few studies have examined these features in Asian population, and none in Singapore.

Design/Methods DESIGN/METHODS: Retrospective review of a prospective clinical database of ischaemic stroke patients in a tertiary clinic setting. Post-stroke patients with memory complaints and magnetic resonance imaging (MRI) scans at stroke presentation were included. Severity of PSCI was defined by clinical history and performance on the mini-mental state examination (MMSE). MRI scans were reviewed by 2 independent raters for location of infarcts; White matter hyperintensity (WMH) was rated using the modified Fazekas scale (range 0-12), microbleeds using Microbleed Anatomical Rating Scale (MARS) and intracranial atherosclerosis using Magnetic Resonance Angiography (MRA) score. We also recorded patients' demographics, cardiovascular risk factors (CVRF) and functional outcomes.

Results RESULTS: 229 patients met the inclusion criteria: 67 had no PSCI, 72 mild PSCI and 90 severe PSCI. Univariate analysis found that presence and severity of PSCI were significantly associated with age, level of education, severity of intracranial atherosclerosis (MRA score 2.5 vs. 2.0; p=0.001), periventricular WMH (modified Fazekas 4.21 vs 3.05; p=<0.001) and deep WMH (modified Fazekas 3 vs. 2; p<0.001). Presence of CVRF, number of microbleeds and location of infarcts were not shown to be significant determinants of PSCI.

Conclusions CONCLUSIONS: Older and less-educated stroke patients with concurrent small vessel and intracranial large artery vessel disease are more likely to have PSCI.

Authors/Disclosures
Xuling Lin, MD (National Neuroscience Institute) PRESENTER	The institution of Dr. Lin has received research support from National Health Innovation Center.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Jeremy C. Hobart, MD (Derriford Hospital)	Dr. Hobart has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Hobart has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi.
	No disclosure on file
Nagaendran Kandiah, MD (National Neuroscience Institute)	No disclosure on file

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