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Abstract Details

Automated Analysis of Retinal Photographs: Results in Subjects with Hypertensive Retinopathy and CADASIL
Neuro-ophthalmology/Neuro-otology
P06 - (-)
009
BACKGROUND: Because of similarities between retinal and cerebral vessels, fundoscopy has been pointed toward as a potential window into the brain microcirculation. Full exploitation of fundoscopy in clinical settings, however, is limited, because currently available tools for assessment of retinal vessels are qualitative or heavily operator-dependent.
DESIGN/METHODS: Retinal photographs were collected from subjects allocated to four groups: subjects with hypertensive retinopathy (n=16), subjects with CADASIL (n=11), and the respective age and gender matched controls (n=16 and 11). Mean-D (a parameter of fractal analysis), arteriole-venule diameter ratio, and Tortuosity Index of the retinal vessels have been carried out by means of two custom software plugins. Analysis of matched case-control data was performed using paired non-parametric mean comparison. Intraclass correlation was estimated as a measure of inter-rater reliability.
RESULTS: We found altered parameters in the hypertensive or CADASIL groups, as compared to the matched control subjects. High inter-rater reliability was observed for all the measurements.
CONCLUSIONS: This method is a simple, almost operator-independent, and highly reproducible way of discriminating pathological conditions characterized by morphological changes of retinal vessels. The advantages include the reduction of analysis time and the minimized operator intervention. The novelty of our approach may improve confidence in fundoscopy as a tool to be exploited in clinical settings or trials.
Authors/Disclosures
Michele Cavallari, MD (Brigham and Woman's Hospital)
PRESENTER 		The institution of Dr. Cavallari has received research support from BrightFocus Foundation. The institution of Dr. Cavallari has received research support from Brigham Research Institute. The institution of Dr. Cavallari has received research support from Department of Radiology at Brigham and Women's Hospital. The institution of Dr. Cavallari has received research support from Hebrew SeniorLife Rehabilitation Center. Dr. Cavallari has received intellectual property interests from a discovery or technology relating to health care.
No disclosure on file
No disclosure on file
James D. Berry, MD MPH (Massachusetts General Hospital) Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Clene Nanomedicine. Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MT Pharma Holdings of America. Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Regeneron. Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MTPA. Dr. Berry has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Berry has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Berry has stock in ReactNeuro. The institution of Dr. Berry has received research support from Biogen. The institution of Dr. Berry has received research support from MT Pharma of America. The institution of Dr. Berry has received research support from Rapa Therapeutics. The institution of Dr. Berry has received research support from Brainstorm Cell Therapeutics. The institution of Dr. Berry has received research support from Alexion. The institution of Dr. Berry has received research support from nQ Medical. The institution of Dr. Berry has received research support from ALSA. The institution of Dr. Berry has received research support from MDA. The institution of Dr. Berry has received research support from Amylyx. The institution of Dr. Berry has received research support from Transposon. Dr. Berry has a non-compensated relationship as a Scientific Advisor with Everything ALS that is relevant to AAN interests or activities.
No disclosure on file