Abstract Details

Title The Relationship Between Cortical Thickness and Semantic Fluency in Clinical and Pre-Clinical Alzheimer's Disease

Topic Aging and Dementia

Presentation(s) P06 - (-)

Poster/Presentation
Number 037

Objective

Background BACKGROUND: Alzheimer's disease is a progressive dementia characterized by declarative memory loss, language difficulties, and behavioral changes. Examining the associations between cortical atrophy and cognitive performance may help further elucidate the underpinnings of this disorder.

Design/Methods DESIGN/METHODS: Structural magnetic resonance images (MRI) were collected from 9 Normal (NC), 40 Mild Cognitive Impairment (MCI), and 10 probable AD subjects as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). Subjects were administered the Category Fluency (CF) animals and vegetables tests. A computational anatomy-based cortical thickness technique was applied to the MRI scans. Linear regression models were applied to detect associations between performance on the semantic fluency tests and cortical atrophy in each cerebral hemisphere.

Results RESULTS: In the CF animals and vegetables tests, poorer semantic fluency was associated with bilateral cortical atrophy of the inferior parietal lobule (Brodmann areas (BA) 39 and 40) and BA 4 and 6 in the frontal lobe. More diffuse frontal associations were seen in the left hemisphere, involving BA 9, 10, 32, 44, 45, and 46. Additional cortical atrophy was seen in the temporoparietal (BA 37) and right peristriate (BA 19, 18) cortex. Associations were far more diffuse for the vegetable category than for the animal category. The permutation-corrected map-wise significance for CF animals was pcorrected=0.01 for the left hemisphere, and pcorrected=0.06 for the right hemisphere. The permutation-corrected map-wise significance for CF vegetables was pcorrected=0.009 for the left hemisphere, and pcorrected=0.03 for the right hemisphere.

Conclusions CONCLUSIONS: These results demonstrate the profound effect of cortical atrophy on semantic fluency. Specifically, our results show that cortical atrophy in the frontal and temporoparietal regions, which have been previously implicated in tapping into semantic knowledge, negatively impacts semantic fluency.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Kristy Hwang	No disclosure on file
	No disclosure on file
Nicole Chow	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Paul M. Thompson, PhD (USC)	No disclosure on file
Liana Apostolova, MD, FAAN (Indiana University School of Medicine)	Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NIH. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for siemens. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. Apostolova has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Association. The institution of Dr. Apostolova has received research support from Roche Diagnostics. The institution of Dr. Apostolova has received research support from NIA. The institution of Dr. Apostolova has received research support from Alzheimer Association. The institution of Dr. Apostolova has received research support from AVID radiopharmaceuticals. The institution of Dr. Apostolova has received research support from Life Molecular Imaging. Dr. Apostolova has a non-compensated relationship as a advisor with FDA that is relevant to AAN interests or activities.

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