Abstract Details

Title Early Postoperative Language Changes in Right and Left Mesial Temporal Sclerosis

Topic Epilepsy

Presentation(s) P06 - (-)

Poster/Presentation
Number 161

Objective

Background BACKGROUND: Cognitive outcomes after epilepsy surgery are a concern.

Design/Methods DESIGN/METHODS: We studied 20 left (L) and 12 right (R) MTS patients and 15 controls (C). Subjects were right-handed, aged between 18 and 55, had eight or more education years, and underwent a language battery including phonemic and semantic fluency (SF), visual confrontation (object, action, and proper noun), and responsive naming, one month prior and three months after surgery. All patients had left hemisphere language dominance. Mean group comparison was performed with ANOVA, covaried for education. Postoperative performance was evaluated with paired t-tests. Reliable change indices (RCI) were calculated. Significance level was p<0.05.

Results RESULTS: Subjects did not differ in age, education years and gender. Patients did not differ concerning occurrence and age at initial insult, silent period duration, age at epilepsy onset, and epilepsy duration. At baseline, LMTS and RMTS performed worse than C in SF (L=15.8+/-4.0;R=15.0+/-3.5;C=19.2+/-4,0;p=0.04) and proper noun naming (PNN) (L=4.1+/-2.8;R=5.5+/-2.5;C=8.3+/-2.8;p=0.001). RMTS performed worse than C in action naming (AN) (L=25.8+/-4.3;R=24.6+/-4.2;C=28.1+/-2.9;p=0.016). Groups did not differ in the other tests. In postoperative testing, LMTS and RMTS showed decline in SF (z:L=-1.3+/-1.7,p=0.02;R=-0.8+/-1.2,p=0.024). LMTS showed decline in PNN(z=-0.5+/-0.8,p=0.01). RMTS showed improvement in AN (z=1.1+/-1.3). All other tests did not show significant changes. RCI showed stable performance in the majority of patients for all tasks. 25% of LMTS and 16.7% of RMTS declined in SF; 15% of LMTS declined in PNN.

Conclusions CONCLUSIONS: Language function showed specific patterns of postoperative change in LMTS and RMTS. LMTS declined in SF and PNN, while RMTS declined in SF, but improved in AN. Other language functions remained stable for both groups. Significant decline in SF and PNN affected a minority of patients.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Rosa M. Valerio, PhD	No disclosure on file
	No disclosure on file
Luiz H. Castro, MD (University of Sao Paulo)	Dr. Castro has nothing to disclose.
Tanuja Chitnis, MD, FAAN (Brigham and Women's Hospital)	Dr. Chitnis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Chitnis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche-Genentech. Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Octave Biosciences. Dr. Chitnis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. The institution of Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Dr. Chitnis has received research support from Novartis. The institution of Dr. Chitnis has received research support from Sanofi. The institution of Dr. Chitnis has received research support from Octave. The institution of Dr. Chitnis has received research support from Genentech-Roche. The institution of Dr. Chitnis has received research support from Tiziana Life Sciences. The institution of Dr. Chitnis has received research support from Bristol-Myers Squibb. The institution of Dr. Chitnis has received research support from Wesley Clover.

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