Abstract Details

Title Diabetes Is Associated with Increased Central Neurotoxicity in Parkinson Disease: A Case-Control Study

Topic Movement Disorders

Presentation(s) P06 - (-)

Poster/Presentation
Number 098

Objective

Background BACKGROUND: There is an increasing interest in studying the interaction between metabolic syndromes and neurodegeneration. Diabetes is thought to contribute to cognitive impairment in the elderly but its effect in PD has not been well studied.

Design/Methods DESIGN/METHODS: We performed a case-control study involving 12 subjects with PD and DM (age 66.9±6.3; duration of disease 6.1yrs±4.5) compared to 24 age, gender and duration-of-disease-matched subjects with PD but without DM. All subjects underwent volumetric MRI, dopaminergic (DTBZ), cholinergic (PMP) PET imaging and neuropsychological assessment. Freesurfer software (http://surfer.nmr.mgh.harvard.edu) was used to define cortical and subcortical MR gray and supratentorial white matter volumes.

Results RESULTS: ANCOVA comparing global cognitive Z-scores between the two PD groups showed a significant effect for DM (F=4.91, P=0.035) with lower scores in the PD with DM compared to the non-diabetic group while controlling for covariate effects of age, education, striatal dopaminergic and cortical cholinergic activity. Analysis of the MRI data showed significant lower cortical (-7.3%, P=0.035), subcortical gray (-8.2%, P=0.0086) and supratentorial white matter (-15.8%, P=0.0001) volumes in the PD diabetic compared to the non-diabetic group.

Conclusions CONCLUSIONS: Comorbid presence of diabetes is associated with increased central neurotoxicity manifested by more severe cognitive deficits and cerebral atrophy in PD. More aggressive management of diabetes may ameliorate aggravated cognitive morbidity in PD diabetics.

Authors/Disclosures
Nicolaas I. Bohnen, MD, PhD, FAAN (University of Michigan) PRESENTER	Dr. Bohnen has stock in Delta. The institution of Dr. Bohnen has received research support from NIH. The institution of Dr. Bohnen has received research support from VA. Dr. Bohnen has received research support from NIH. The institution of Dr. Bohnen has received research support from Parkinson fnd.
	No disclosure on file
Vikas Kotagal, MD, FAAN (University of Michigan)	Dr. Kotagal has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorders Society. The institution of Dr. Kotagal has received research support from NIH. The institution of Dr. Kotagal has received research support from VA Healthcare System.
Martijn Muller, PhD (Critical Path Institute)	No disclosure on file
	No disclosure on file
Kirk A. Frey, MD, PhD (Univ of Michigan/Univ Hosp BIG 412 0028)	No disclosure on file
Roger L. Albin, MD (University of Michigan)	Dr. Albin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Dr. Albin has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Albin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Albin has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vaccinex. The institution of Dr. Albin has received research support from NIH-NINDS. The institution of Dr. Albin has received research support from Parkinson's Foundation. The institution of Dr. Albin has received research support from Michael J. Fox Foundation. Dr. Albin has received personal compensation in the range of $5,000-$9,999 for serving as a Grant Application Reivewer with Michael J. Fox Foundation.
David S. Knopman, MD, FAAN (Mayo Clinic)	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.

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