Abstract Details

Title CKD-EPI Formula Is Superior to MDRD in Assessment of Glomerular Filtration Rate as the Outcome Predictor in Ischemic Stroke Patients

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 266

Objective

Background BACKGROUND: A lowered glomerular filtration rate (GFR) leads to stroke unfavorable outcome. Recently, a new equation (Chronic Kidney Disease Epidemiology Collaboration, CKD-EPI) for the estimation of GFR was proposed in addition to the Modification of Diet in Renal Disease (MDRD) formula.

Design/Methods DESIGN/METHODS: We included in the study 468 consecutive ischemic stroke patients scored on admission with the National Institutes of Health Stroke Scale (NIHSS) and with the modified Rankin Scale (mRS) and Barthel index (BI) to assess outcomes at 30, 90, 180 and 360 days.

Results RESULTS: Only GFRCKD-EPI correlated with the NIHSS score (r=-0.097; P=0.031) on admission and with the BI at day 360 after stroke onset (r=0.25; P=0.040). The odds ratios (OR) of an unfavorable stroke outcome (mRS>2) during the 30th-360th day follow-up at GFR<60 mL/min/1.73 m2 increased if the GFRCKD-EPI (not the GFRMDRD) was calculated. The OR of death at GFR<60 mL/min/1.73 m2 was higher if the CKD-EPI formula was used (OR=3.72; P<0.0001) than if the MDRD equation was used (OR=2.84; P<0.0001). In stroke patients with a history of myocardial infarct, a higher GFRCKD-EPI (but not GFRMDRD) was independently associated with a lower risk of death (OR=0.775; P=0.037).

Conclusions CONCLUSIONS: The CKD-EPI formula is superior to the MDRD equation as a predictor of outcomes in stroke patients, and this measure is particularly relevant for stroke patients who have a history of myocardial infarct.

Authors/Disclosures
Slawomir Michalak, PhD PRESENTER	No disclosure on file
Radoslaw Kazmierski, MD, PhD (SP ZOZ MSW Hospital)	Dr. Kazmierski has nothing to disclose.
	No disclosure on file
	No disclosure on file
Wojciech Kozubski, MD, PhD (University of Medical Sciences in Poznan)	No disclosure on file
Edward J. Cupler, MD, FAAN (King Faisal Specialist Hospital and Research Center)	Dr. Cupler has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi.

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