Abstract Details

Title Magnetoencephalography of Deep Brain Stimulation in a Patient with ET/PD Syndrome

Topic Movement Disorders

Presentation(s) P06 - (-)

Poster/Presentation
Number 089

Objective

Background BACKGROUND: The cortical effects of deep brain stimulation (DBS) therapy in Essential tremor (ET) and Parkinson's disease (PD) patients are not well described, given the limitation of most functional imaging tools in identifying motor cortical activity on the same time-scale as expression of motor behavior.

Design/Methods DESIGN/METHODS: Magnetoencephalography (MEG) recordings were obtained during no therapy (0 V), subtherapy (1 V), and therapy (3 V) with unilateral and bilateral DBS.

Results RESULTS: Dipole source localization in reference to the postural tremor frequency recorded with electromyography (EMG) showed prominent sources in both right and left motor cortices when no therapy was provided. These sources dissipated as the amplitude of stimulation increased to a therapeutic level (p = 0.006). Coherence peaks between the EMG and MEG recordings were seen at both 4 Hz, postural tremor frequency, and at 8 Hz, twice the tremor frequency, with no therapy. Both peaks were reduced with therapeutic DBS.

Conclusions CONCLUSIONS: These results demonstrate the capabilities of MEG to record cortical dynamics of tremor during deep brain stimulation and suggest that MEG could be used to examine DBS in the context of motor signs of PD and of ET.

Authors/Disclosures
PRESENTER	No disclosure on file
Jawad Bajwa, MD (King Fahad Medical City)	No disclosure on file
	No disclosure on file
	No disclosure on file

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