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Abstract Details

Neuroanatomical Correlates of Symptoms on the Frontal Systems Behavior Scale in Frontotemporal Dementia and Early-Onset Alzheimer's Disease
Aging and Dementia
P06 - (-)
048
BACKGROUND: Patients with younger-onset forms of dementia, such as bvFTD and EOAD, tend to exhibit more frontal-executive symptoms compared to patients with late-onset Alzheimer's disease. We used tensor-based morphometry (TBM) to map the association between regional brain volumes and caregiver ratings on the Frontal Systems Behavior Scale (FrSBe) in bvFTD and EOAD patients.
DESIGN/METHODS: Caregivers of 19 study participants (mean age=59.3, sd=8.0), including 9 bvFTD and 10 EOAD patients, completed the FrSBe, yielding 3 subscale scores (Apathy, Disinhibition, Dysexecutive) and a Total score. TBM was applied to 3D T1-weighted MRI scans for each participant. Each individual image was warped to a common brain template, and Jacobian maps showing the expansion or compression factor at each voxel were created. Mean Jacobian values within selected regions of interest were computed for each subject to provide a numeric summary of regional volume. Voxel-wise regression of FrSBe scores was performed on the Jacobian maps.
RESULTS: None of the FrSBe subscales or Total scores were significantly correlated with overall frontal lobe volume (Apathy: r=-.18, p=.45; Disinhibition: r=-.08, p=.74; Dysexecutive: r=-.16, p=.51; Total: r=-.16, p=.53). Examination of more specific frontal regions revealed that dorsolateral prefrontal volume showed non-significant correlations similar to overall frontal volume. However, orbitofrontal volume was significantly correlated with Apathy subscale scores (r=-.52, p=.02), and showed a marginally significant correlation with FrSBe Total scores (r=-.43, p=.07). Correlations between orbitofrontal volume and Disinhibition (r=-.28, p=.24) and Dysexecutive (r=-.37, p=.12) subscales did not reach significance.
CONCLUSIONS: Although the FrSBe is a measure of frontal-executive dysfunction, the symptoms assessed by the FrSBe, especially apathy, seem to be associated more specifically with the orbitofrontal cortex, rather than the dorsolateral prefrontal cortex or overall frontal volume.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Salvador Cruz-Flores, MD, FAAN (Paul L. Foster School of Medicine Texas Tech University Health Sciences Center) The institution of Dr. Cruz-Flores has received research support from University of Texas System.
Natalie Kaiser (West Los Angeles VA Medical Center) No disclosure on file
No disclosure on file
Paul M. Thompson, PhD (USC) No disclosure on file
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.