好色先生

好色先生

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Abstract Details

FDG-PET Reveals Reduced Metabolic Activity in the Basal Ganglia of a Patient with Anti-NMDA Receptor Encephalitis
Neurotoxicology
P06 - (-)
222
BACKGROUND: Hyperactivity in the basal ganglia noted on FDG-PET imaging has been associated with clinical severity in patients with ANRE. Other studies have indentified a frontotemporal to occipital gradient as being characteristic of ANRE.
DESIGN/METHODS: We describe a 19-year-old Hispanic male with presented with altered mental status, unusual behavior, orofacial dyskinesias, rigidity, and diaphoresis. The results of the patient's FDG-PET (see Figure 1) are discussed.
RESULTS: The patient underwent a lumbar puncture. Analysis of the cerebrospinal fluid revealed anti-NMDA receptor antibodies. The patient continued to experience involunatary movements despite pulsed dose steroids, IVIG, plasmapheresis, rituximab, and cyclophosphamide. FDG-PET imaging revealed a distinct region of reduced uptake in the basal ganglia, bilaterally (see Figure 1). DNA testing for Huntington's Disease was negative.
CONCLUSIONS: Past reports suggest a possible correlation between basal ganglia hypermetabolism and clinical manifestations, thus the reduced basal ganglia metabolism seen in our patient was unexpected. We propose that the altered basal ganglia metabolism seen in our patient was associated with his involuntary movements. Further investigations will be necessary to determine the specific structural and metabolic abnormalities in the basal ganglia of ANRE patients. Additionally, our patient did not manifest a FDG-PET frontotemporal to occipital gradient, which has been described as a characteristic finding in ANRE.
Authors/Disclosures
Michael S. Abers
PRESENTER 		No disclosure on file
Sahar Zafar, MD Dr. Zafar has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. Dr. Zafar has received research support from NIH. Dr. Zafar has received personal compensation in the range of $5,000-$9,999 for serving as a Speaker for a lecture with Marinus.
Joseph S. Kass, MD, JD, FAAN (Baylor College of Medicine) Dr. Kass has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for 好色先生 . Dr. Kass has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Kass has received personal compensation in the range of $100,000-$499,999 for serving as an Expert Witness for Multiple Law Firms . Dr. Kass has received publishing royalties from a publication relating to health care.
Sung Lee No disclosure on file