Abstract Details

Title Heart Rate Variability in Acute Ischemic Stroke: Topographical Mapping of Cerebral Autonomic System

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P06 - (-)

Poster/Presentation
Number 270

Objective

Background BACKGROUND: Multiple studies have shown that heart rate variability in acute stroke is associated with poor clinical outcome. Stroke involving the insula, cingulate, amygdala, hypothalamus, and brainstem structures have been associated with cardiac arrhythmias. There is currently no available data describing susceptibility to heart rate variability with specific cerebral vascular territory dysfunction.

Design/Methods DESIGN/METHODS: A chart review was performed on all patients (n=384) diagnosed to have acute ischemic stroke in a tertiary stroke center from 2008 to 2011. Patients with non-acute stroke, cerebral hemorrhage, and primary heart conditions were excluded. A total of 276 patients were enrolled. Student T-test was used for continuous variables, and fisher exact test for categorical variables.

Results RESULTS: In right anterior cerebral artery (ACA) stroke, 0% had brady- and 50% had tachyarrhythmias; and equal number(11.1%) in left ACA stroke. In left middle cerebral artery (MCA)stoke,6.4% had brady- and 21.8% had tachyarrhythmias. In right MCA stroke,5.3% had brady- and 10.7% had tachyarrythmias. In left posterior cerebral artery (PCA) stroke, 12% had brady- and 4% had tachyarrhythmias. In right PCA stroke, 4.2% had brady- and 25% had tachyarrythmias. Patients with vertebrobasilar stroke were found to have brady- in 6.9% and tachyarrhythmias in 10.3%. There was no statistically significant difference between left versus right ACA, MCA, and PCA brady-, as well as left versus right ACA and MCA tachyarrhythmias. A statistically significant difference was found in left versus right PCA (p<0.04) tachyarrhythmias.

Conclusions CONCLUSIONS: We found that tachyarrhythmias were statistically significant in right PCA distribution ischemic stroke. Our study indicates that right PCA distribution ischemic infarcts may need close cardiac monitoring and heart rate control. No significant statistical difference were seen in ACA and MCA distribution strokes.

Authors/Disclosures
Paul Eugene P. Lleva, MD, FAAN (White Plains Hospital) PRESENTER	Dr. Lleva has nothing to disclose.
Reshma Gokaldas, MD	No disclosure on file
Ramandeep Sahni, MD (WMCHealth Advanced Physician Services)	Dr. Sahni has nothing to disclose.
Judith Bellmann-Strobl, MD (Bharite University of Medicine Berlin)	Judith Bellmann-Strobl, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Judith Bellmann-Strobl, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Judith Bellmann-Strobl, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme. Judith Bellmann-Strobl, MD has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. The institution of Judith Bellmann-Strobl, MD has received research support from Bayer. The institution of Judith Bellmann-Strobl, MD has received research support from NEMOS.

��ɫ��

��ɫ��