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Abstract Details

Comparing 3T and 1.5T MRI for Mapping Hippocampal Atrophy in the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Aging and Dementia
P06 - (-)
029
BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative dementia. Prior magnetic resonance imaging (MRI) studies, primarily at 1.5T, established hippocampal atrophy as a biomarker for AD.
DESIGN/METHODS: We analyzed baseline MRI data from 166 ADNI subjects (37 AD, 76 mild cognitive impairment (MCI) and 53 normal controls (NC)) scanned at 1.5T and 3T. Using multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for age. 3D statistical maps were adjusted for multiple comparisons using permutation-based statistics with a threshold of p<0.01.
RESULTS: Bilateral significant differences in the CA1, CA2 and subiculum were detected for AD vs NC at 1.5T (pleft=0.0006, pright=0.0018) and more profoundly at 3T (pleft=0.0001, pright=0.0001). MCI vs NC showed significant bilateral atrophy in the CA1, CA2 and subiculum at 1.5T (pleft=0.0004, pright=0.0012) and again more so at 3T (pleft=0.0001, pright=0.0001). AD/MCI comparisons showed no significant differences in both 1.5T (pleft=0.52, pright=0.91) and 3T (pleft=0.81, pright=0.54). MCI subjects who converted to AD within three years vs the non-converters did not show significant differences at 1.5T (pleft=0.80, pright=0.74), but did in the CA1 of the right hippocampus at 3T (pleft=0.06, pright=0.01). Differences between MCI imminent converters and non-converters did not reach significance at 1.5T (pleft=0.64, pright=0.26) but did reach significance for the right hippocampus at 3T (pleft=0.08, pright=0.03).
CONCLUSIONS: Hippocampal atrophy patterns in diagnostic comparisons were similar at 1.5T and 3T, but 3T scans revealed more expansive atrophy and differences not apparent at 1.5 T. 3T imaging may serve as a powerful tool for predicting AD conversion.
Authors/Disclosures
Nicole Chow
PRESENTER 		No disclosure on file
Kristy Hwang No disclosure on file
No disclosure on file
Paul M. Thompson, PhD (USC) No disclosure on file
Clifford R. Jack, Jr., MD (Mayo Clinic) The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Michael W. Weiner, MD Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Dolby Family Ventures. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmaceuicals. Dr. Weiner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Acumen Pharmaceuticals. Dr. Weiner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Guidepoibnt. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Owkin France. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Quantum Leap Health. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sai MedPartners. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MEDA Corp.. Dr. Weiner has stock in Anven. Dr. Weiner has stock in Alzeca. Dr. Weiner has stock in Alzheon, Inc.. Dr. Weiner has stock in ALZpath. The institution of Dr. Weiner has received research support from NIH/NIA; National Institutes of Health/National Institutes of Aging. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Speaker/Presenter with Merck Sharp & Dohme. Dr. Weiner has received personal compensation in the range of $0-$499 for serving as a Speaker/Presenter with BrightFocus Foundation. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Speaker/Presenter with Banner Health.
Liana Apostolova, MD, FAAN (Indiana University School of Medicine) Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NIH. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for siemens. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. Apostolova has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Association. The institution of Dr. Apostolova has received research support from Roche Diagnostics. The institution of Dr. Apostolova has received research support from NIA. The institution of Dr. Apostolova has received research support from Alzheimer Association. The institution of Dr. Apostolova has received research support from AVID radiopharmaceuticals. The institution of Dr. Apostolova has received research support from Life Molecular Imaging. Dr. Apostolova has a non-compensated relationship as a advisor with FDA that is relevant to AAN interests or activities.
Val J. Lowe, MD (Mayo Clinic) Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals.