Abstract Details

Title Increase CSF Hypocretin-1 Levels Is Associated with HIV-Associated Neurocognitive Disorders

Topic Infections/AIDS/Prion Disease

Presentation(s) P06 - (-)

Poster/Presentation
Number 185

Objective

Background BACKGROUND: Hypocretin/orexin (hcrt/ox) system is composed of hypothalamic peptides that have been related to narcolepsy/insomnia, obesity, and motivational behaviors. The relationship of hcrt/ox levels to dementia is unclear. Recently hypothalamic dysfunction was shown to be associated with mood disorders in drug abusing HIV-seropositive patients.

Design/Methods DESIGN/METHODS: Retrospective study of 55 HIV-seropositive women and 5 CSF controls, patients were stratified by cognitive performance. All participants had a negative toxicology. HAND was determined using a modified AAN HIV dementia criteria and divided into 3 groups, normal cognition (n=13), asymptomatic impairment (n=18) and symptomatic impairment (MCMD + HAD, n=24). No differences in age, education, viral load (plasma and CSF), CD4 (current and nadir), hepatitis C virus, BMI, BDI, and HAND were observed between groups. CSF hcrt/ox levels were determined using the fluorescent immunoassay kit, (Phoenix Pharmaceuticals) with an intra- and inter-assay validity of 10% and 15% respectively. The association between CSF hcrt/ox and HAND was tested using parametric and non parametric statistics, as appropriate. Statistical significance was determined at p<.05.

Results RESULTS: No significant differences were observed between CSF hcrt/ox levels of HIV-seropositive and seronegative controls. No correlations were observed between CSF hcrt/ox levels and age, BDI, BMI, and viral immune profile. An association was observed between CSF hcrt/ox levels and HAND (p=0.02), where the HIV cognitively impaired groups had higher levels than the HIV normal cognition group. A negative correlation was observed between CSF hcrt/ox levels and NPZ and psychomotor speed and verbal memory domains (p<0.05).

Conclusions CONCLUSIONS: Our findings suggest that CSF hcrt/ox levels may have a role in the presence and severity of HAND. Further studies should be performed to support current findings.

Authors/Disclosures
Valerie E. Wojna, MD, FAAN (Nuerology Division, UPR MSC SoM) PRESENTER	Dr. Wojna has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Puerto Rico Health Sciences Journal, University of Puerto Rico Medical Sciences Campus. The institution of Dr. Wojna has received research support from NIH.
	No disclosure on file
	No disclosure on file
Stephen B. Tatter, MD (Wake Forest Univ School of Medicine)	The institution of Dr. Tatter has received research support from Monteris Medical, Inc. The institution of Dr. Tatter has received research support from Arbor Pharmaceuticals. Dr. Tatter has received intellectual property interests from a discovery or technology relating to health care.
	No disclosure on file
	No disclosure on file
Richard L. Skolasky, BA	No disclosure on file

��ɫ��

��ɫ��