Abstract Details

Title Early Ipsilesional Hippocampal Atrophy Occurs after Both Anterior and Posterior Circulation Strokes

Topic Aging and Dementia

Presentation(s) P06 - (-)

Poster/Presentation
Number 052

Objective

Background BACKGROUND: There is evidence that some brain regions, especially the hippocampi, exhibit atrophy after stroke. We have reported changes in the post-stroke period in a cohort of patients with middle cerebral artery stroke, and sought here to corroborate these findings in a group of prospectively recruited patients with both anterior and posterior circulation stroke.

Design/Methods DESIGN/METHODS: Acute ischemic stroke patients were imaged within 40 days of symptom onset and at 3 months. Healthy control participants were also imaged at baseline and 3 months. 3D MPRAGE images were acquired on a Siemens Trio 3T MRI scanner (TE=2.55 ms, TI=900 ms, TR=1900 ms, flip angle = 9[ordm], voxel=1 mm isotropic). Images were processed using Freesurfer V 5.1 with default settings. Patients completed a memory assessment (Hopkins Verbal Learning Test-Revised) at both time points. We compared baseline and 3 month average regional cortical thickness and hippocampal volume, calculating individual percentage change scores. Ipsilesional and contralesional results were analyzed separately. Change scores were also computed for memory performance. Paired sample t-tests were used to assess significant change.

Results RESULTS: Sixteen stroke patients were included (14 men; 9 left; mean age=66.9±8.7, range 53-82 years; years of education 15±4, range 9-24 years; mean NIHSS 3.5±2.5, range 1-10; 3 LACI, 6 PACI, 7 POCI) and 10 healthy controls (5 men, mean age 67.2±3; years of education 11±5). A significant decrease in ipsilesional, but not contralesional, hippocampal volume was found (p = 0.043). This was found in patients with both anterior and posterior circulation strokes. No significant changes in cortical thickness or in memory performance were identified.

Conclusions CONCLUSIONS: In conclusion, we found that ipsilesional hippocampal atrophy occurs in the subacute post-stroke period in patients with both anterior and posterior circulation stroke, even in the absence of early memory decline.

Authors/Disclosures
Amy Brodtmann, MBBS, PhD, FRACP (Monash University) PRESENTER	Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk. Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medicines Australia. Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eli Lilly. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Macpherson Kelley. The institution of Prof. Brodtmann has received research support from National Health and Medical Research Council. The institution of Prof. Brodtmann has received research support from Medical Research Future Fund. The institution of Prof. Brodtmann has received research support from National Heart Foundation. The institution of Prof. Brodtmann has received research support from Victorian Medical Research Acceleration Fund. Prof. Brodtmann has a non-compensated relationship as a Honorary Medical Advisor with Dementia Australia that is relevant to AAN interests or activities. Prof. Brodtmann has a non-compensated relationship as a Brain Health Initiative with Australian Football League that is relevant to AAN interests or activities.
Heath Pardoe	No disclosure on file
Qi Li, MD, PhD	No disclosure on file
Paul C. Van Ness, MD, FAAN	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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