Abstract Details

Title Improved Naming after Excitatory Repetitive Deep Transcranial Magnetic Stimulation over the Right Homologous Broca's Region in Chronic Post-Stroke Aphasia

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) IN11 - (-)

Poster/Presentation
Number 002

Objective

Background The role of right hemisphere in post-stroke aphasia recovery is still controversial and nowadays there is no consistency in literature about the therapeutic effects of repetitive transcranial magnetic stimulation over the right homologous Broca region.

Design/Methods Five post-stroke chronic aphasic patients underwent a picture naming task before and immediately after each of three sessions of rTMS with excitatory (10 Hz), inhibitory (1 Hz) and sham rTMS respectively, in random sequence and separated by at least one week.

Results Only the excitatory stimulation was associated to a significant improvement in naming performance with respect to baseline (p=0.04) and with 1Hz rTMS (p=0.04) while a trend was observed in comparison with sham stimulation (p=.0.1).

Conclusions A single session of excitatory deep brain rTMS on the right inferior frontal gyrus with H-coil significantly improves naming in chronic aphasic post-stroke right-handed patients. This result suggests that the right hemisphere may play a positive, rather than detrimental role, in the recovery of aphasia occurring after a left-hemispheric stroke in right handed subjects.

Authors/Disclosures
Raffaella Chieffo, MD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Arturo Nuara	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Stefano F. Cappa, MD	Dr. Cappa has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elservier. The institution of Dr. Cappa has received research support from Italian Minsitry of Health.
Letizia M. Leocani, MD (University Vita-Salute San Raffaele, INSPE)	Dr. Leocani has received personal compensation in the range of $0-$499 for serving as a Consultant for Roche . Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Med-ex learning.
Laurence Mignon, PhD (Ionis Pharmaceuticals, Inc)	No disclosure on file

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