好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Risk Factors for Parkinson's Disease Differ in Men and Women
Movement Disorders
IN8 - (-)
007
Although several environmental and genetic risk or protective factors have been associated with Parkinson's disease (PD), their interactions overall and in men and women separately remain unknown.
We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (卤1 year) and sex to a general population control. We considered the following 12 risk or protective factors: personal history of head trauma, pesticide use, immunologic diseases, anemia, hysterectomy (in women only), cigarette smoking, coffee consumption, and education; and family history of parkinsonism, essential tremor, dementia, or psychiatric disorders. We used recursive partitioning analyses to explore interactions overall and in men and women separately and used logistic regression analyses to test for possible interactions.
In the overall group, we observed the independent effects of anemia, lack of coffee consumption (never vs. ever), and head trauma; however, the findings were different in men and women. In men, we observed the independent effects of lack of coffee consumption (never vs. ever), head trauma, and pesticide use, and a suggestive synergistic interaction between immunologic diseases and family history of dementia. By contrast, in women, anemia was the most important factor and we observed a suggestive synergistic interaction between anemia and higher education.
Risk factors for PD and their interactions may differ in men and women.
Authors/Disclosures
Rodolfo Savica, MD, PhD, FAAN (Mayo Clinic)
PRESENTER 		The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc.
Brandon R. Grossardt, MS (Mayo Clinic College of Medicine) No disclosure on file
James H. Bower, MD, MSc, FAAN (Mayo Clinic) The institution of Dr. Bower has received research support from Abbvie.
J. E. Ahlskog, MD, PhD (Mayo Clinic) Dr. Ahlskog has received publishing royalties from a publication relating to health care.
No disclosure on file
Walter A. Rocca, MD, MPH The institution of Dr. Rocca has received research support from National Institute on Aging - NIH. The institution of Dr. Rocca has received research support from National Heart, Lung, and Blood Institute - NIH.