Abstract Details

Title Predictive Value of CSF Biomarkers for Alzheimer's Disease in an Italian Cohort of Patients with Mild Cognitive Impairment

Topic Aging and Dementia

Presentation(s) IN3 - (-)

Poster/Presentation
Number 003

Objective

Background There is a growing interest in identifying AD at the early stages as earlier diagnosis is a major goal of health services. Amnestic MCI patient presents a high risk of conversion to AD, while non-amnestic MCI may also convert to other forms of dementia. Recently, several studies reported that CSF biomarkers may be useful in identifying MCI at risk of developing AD.

Design/Methods 88 patients (49 females and 39 males; mean age 68.3 ± 8.2 yrs) were recruited at the Department of Neuroscience, University of Torino, Italy. All patients were diagnosed with MCI, 42% amnestic MCI, 58% non-amnestic MCI. During hospitalization all patients underwent lumbar puncture, and CSF A?-42, T-tau and P-tau concentrations were measured. The following indices were calculated: T-tau/A?-42 ratio, P-tau/A?-42 ratio, and AD CSF profile, calculated as AB-42/ (240 + [1,18 x T-tau]).

Results The initial diagnosis of MCI was re-evaluated at 3 years follow up. A?-42 had an AUC of 0.88, a sensitivity of 86%, and a specificity of 79% to predict AD (cut-off: 500 mg /mL). AD profile had an AUC of 0.97, a sensitivity of 97%, and a specificity of 96% (cut-off: 1).

Conclusions CSF A?-42, T-tau, P-tau evaluation is extremely useful in patients with MCI, in order to assess the probability of progression to Alzheimer's disease. When evaluated together, these CSF biomarkers, show a sensitivity of 89%, a specificity of 77%, a PPV of 73%, and a VPN of 91% in highlighting a CSF alteration predicting AD. In particular, CSF AD profile seems to play an important role as predictive tool in MCI patients.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Lorenzo Pinessi, MD (University of Turin/Dept of Neuroscience)	No disclosure on file
Innocenzo Rainero, MD, PhD (University of Turin)	No disclosure on file
	No disclosure on file

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