Abstract Details

Title Impact of History of Treated Depression on Stroke Outcomes

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S47 - Stroke Outcomes and Recurrence (1:55 PM-2:06 PM)

Poster/Presentation
Number 006

Objective This study compares outcomes among patients treated for ischemic stroke with a history of treated depression versus those without a history of depression or with untreated depression.

Background Depression has been shown to both affect outcomes after stroke and occur as a result of stroke. Less is known about the effect of prior history of treated depression on stroke outcomes, specifically among treated patients.

Design/Methods Data obtained from a multi-hospital system’s stroke registry from January 2010 to August 2018 included patients with a primary or secondary diagnosis of ischemic stroke treated with IV alteplase and/or thrombecotmy. The outcomes were change in ambulation from prior to the stroke to ambulation at discharge (returned to baseline versus poorer ambulation) and discharge disposition (home or inpatient rehabilitation facility (IRF) versus other location). Patients with a history of treated depression were compared to those without a prior depression diagnosis or with untreated depression. Generalized linear models were used to assess outcomes adjusting for treatment type, admission NIHSS, age, and gender.

Results A total of 4,319 and 5,956 patients were included in the analyses for change in ambulation and discharge disposition, respectively. Patients with history of treated depression (n=501) were more likely to return to or maintain baseline ambulation (Adjusted Odds Ratio. (AOR)=1.33, p<.001) compared to those without depression or untreated depression. The likelihood of discharge to home or IRF for those with treated depression (n=637) approached but did not reach significance (AOR=1.30, p=.070).

Conclusions Results suggested that among treated patients, those with a history of treatment for depression were more likely to have better ambulation than those without a history of depression or those with untreated depression. This could indicate that prior depression treatment may play a role in resiliency after stroke.

Authors/Disclosures
Elizabeth A. Baraban, PhD, MPH (Providence Health and Services) PRESENTER	The institution of Dr. Baraban has received research support from Boehringer Ingelheim.
Lindsay Lucas (Providence Health and Services)	No disclosure on file

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