To analyze and compare amyloid-β(Aβ) deposition, brain metabolism andneuropsychological profile of healthy controls (HC), Subjective cognitive decline and “SuperAgers” . 

Subjective cognitive decline (SCD) is a potential risk factor for dementia. On the other hand, the group recently known as “SuperAgers” (SA), elderly aged 80+ who have a memory equivalent to 20-30 years younger, present greater resilience to age-related cortical atrophy. 

SCD was defined from the questionwhether the subject feels that his memory is worsening. SA was required to perform at or above average normative values for individuals in their 50-60s in delayed recall score of the Rey Auditory Verbal Learning Test. They were evaluated with the Clinical Dementia Rating scale (CDR), Mini Mental Status Examination (MMSE), Montreal Cognitive Assessment (MoCA), Brief Cognitive Screening Battery and a standard neuropsychological battery. Images of 11C-PIB and 18F-FDG were acquired in a hybrid PET/MR equipment and analyzed individually using cross-sectional images and with 3D-SSP methodology. For the between-groups comparison, we used the SPM8 software. 

Eighty-nine elderly individuals were included, being 25 HC, 49 SCD and fifteen SA. For the whole sample, mean age and schooling were 75.1 (±8.3) and 14.2 (±4.4) years, respectively. The SCD group had more anxiety and depressive symptoms. There were also no significant differences in cognitive tests between SCD and HC, but SA group have best performance in memory tests. SCD exhibited no significant differences in Aβdeposition when compared with HC (11/42 vs. 4/17, respectively). Five from twelve SA presented positive amyloid in visual analysis. In the group comparison, corrected for age and schooling, SA presented higher metabolism in pre-frontal and anterior cingulate cortex compared to HC and SCD. 

SCD and HC were similar groups. There was a higher prevalence in cortical amyloids in SA in relation to other groups, but SA presented higher metabolism frontal and anterior cingulate cortex.