Abstract Details

Title Trends and Predictors of In-hospital Mortality for Status Epilepticus: National Inpatient Sample Study 2005-2014

Topic Neuro Trauma, Critical Care, and Sports Neurology

Presentation(s) S48 - Neurocritical Care: Traumatic Brain Injury and Goals-of-care Decision-making (2:12 PM-2:24 PM)

Poster/Presentation
Number 007

Objective

This study investigates trends and predictors of in-hospital mortality due to Status Epilepticus at national level in United States.

Background A recent systematic review indicates that the mortality of status epilepticus (SE) is about 15.9% with a non significant downward trend in recent years. Mortality has not changed much despite aggressive management.

Design/Methods

We performed a cross-sectional analysis using the Nationwide Inpatient Sample (NIS), 2005–2014, of US adult hospitalizations with Status Epilepticus.

Annual rate of in-hospital mortality was calculated using NIS weighting. We identified our Status Epilepticus patient subset from using codes (DX1 = 345.3) from the International Classification of Diseases, 9th edition.

Potential factors associated with in-hospital mortality were assessed using logistic regression.

Results

Of 147,548 hospitalized patients with Status Epilepticus, 5,271 (3.57%) died during the index hospitalization.

Across 2005–2014, 3.57% of SE patients died; with a downward but not statistically significant trend in-hospital mortality from 4.28% (2005) to 3.73% (2014) (p = 0.14).

SE patients with in-hospital mortality were more likely to be women, older, and with a higher proportion of medical co-morbidities, in-hospital complications and extreme loss of function as per All Patients Refined Diagnosis Related Groups (APR DRG).

Signi?cant factors associated with higher mortality were female gender, age ≥ 65 yrs, teaching hospital status, renal failure, APR DRG severity, mechanical ventilation, tracheostomy, sepsis, pulmonary embolism, acute kidney injury and respiratory insufficiency.

Conclusions

Mortality due to SE was lower than previously reported. Mortality has had a non-significant downward trend in the years studied. Age, female gender, medical complications and poor baseline functional status are important predictors.

Availability of aggressive treatment has not modified significantly mortality which requires further study.

Authors/Disclosures
Huy Q. Nguyen, MD PRESENTER	No disclosure on file
Mohammad Rauf A. Chaudhry, MD	Dr. Chaudhry has nothing to disclose.
Shayan Ul Haque, MD, MBBS	No disclosure on file
Mushtaq H. Qureshi, MD	No disclosure on file
Harathi Bandaru, MD	Dr. Bandaru has nothing to disclose.
Ihtesham A. Qureshi, MD	No disclosure on file
Jorge H. Moreno, MD	No disclosure on file
Guillermina A. Nelson, NP (Texas Tech University Health Sciences Center El Paso)	No disclosure on file
	No disclosure on file
	No disclosure on file
Paisith Piriyawat, MD (Texas Tech University)	Dr. Piriyawat has nothing to disclose.
Alberto Maud, MD (Paul L. Foster School of Medicine Texas Tech UHSC El Paso, Texas)	Dr. Maud has nothing to disclose.
Gustavo J. Rodriguez, MD (Gustavo J. Rodriguez)	Dr. Rodriguez has nothing to disclose.
Salvador Cruz-Flores, MD, FAAN (Paul L. Foster School of Medicine Texas Tech University Health Sciences Center)	The institution of Dr. Cruz-Flores has received research support from University of Texas System.

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