Abstract Details

Title Effect of Ketogenic Diet on Serum Levels of Interleukin-6 and Interleukin-1ß in Pediatric Patients with Drug-resistant Epilepsy

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P13 - Poster Session 13 (5:30 PM-6:30 PM)

Poster/Presentation
Number 12-002

Objective

To evaluate the effect of KD on serum levels of IL-6 and IL-1β in pediatric patients with DRE.

Background

Proinflammatory cytokines play a vital role in epileptogenesis. They are overexpressed in patients with drug-resistant epilepsy (DRE). Among the proinflammatory cytokines, interleukin-6(IL-6) and interleukin-1β(IL-1β) are the most widely explored targets for antiepileptic drug (AED) discovery. We investigated the effect of ketogenic diet (KD), one of the oldest treatments for uncontrolled seizures, on serum IL-6 and IL- 1β levels.

Design/Methods

A total of 31 patients (mean age=5.47 +4.75 years) diagnosed with DRE were enrolled in KD programme over a period of two years. Patients with chronic inflammatory diseases were excluded. Blood samples were collected before the initiation of KD and one year after KD initiation. Serum levels of IL-6 and IL-1β were measured by ELISA. Statistical analyses were performed using Easy R (EZR) software.

Results KD resulted in a significant reduction in serum IL-6 level from 85.26±8.89 pg/ml to 74.87 ± 9.60 pg/ml (p <0.05) and IL-1β level from 9.06 ±6.45 pg/ml to 5.16 ± 3.90 pg/ml (p <0.05) in all the patients irrespective of the seizure subtype. No significant difference was observed in cytokine level reduction between different seizure subtypes. Unlike previous studies, our study failed to demonstrate a positive correlation between the baseline seizure frequency and IL-6 and L-1β levels. Factors such as age of seizure onset and baseline seizure frequency also did not affect the reduction in cytokine levels. Patients who were treated with four or more AEDs had a significantly greater reduction in cytokine levels compared to those on less than four AEDs (p<0.05).

Conclusions

KD caused significant lowering of serum IL-6 and IL-1β levels in patients with DRE. Proinflammatory cytokine downregulation might be one of the antiepileptic mechanisms of KD.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Kurupath Radhakrishnan, MD, FAAN (KIMS HEALTH)	No disclosure on file
	No disclosure on file
Janak K. Nathan, MD (Shushrusha Hospital)	No disclosure on file

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