Abstract Details

Title Cortical amyloid-beta burden is associated with faster weight loss in cognitively normal individuals in late-life: a 6-year longitudinal study

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P3 - Poster Session 3 (12:00 PM-1:00 PM)

Poster/Presentation
Number 10-001

Objective We aimed to investigate the longitudinal relationship of amyloid pathology with late-life BMI.

Background

Higher late-life body mass index (BMI) was associated with reduced risk of Alzheimer’s disease (AD), which might be explained by a reverse causal relationship.

Design/Methods Amyloid burden was assessed by AV45 PET or cerebrospinal fluid biomarkers. Linear mixed effects model was used to evaluate whether amyloid deposition at baseline predicted faster BMI decrease in 238 cognitively normal elders in the Alzheimer’s disease Neuroimaging Initiative (ADNI) database. Moreover, the relationship between amyoid deposition rate during 2 years and BMI change rate during 6 years was explored. All analyses were repeated in the strata of APOE4 status and gender.

Results

Individuals with greater amyloid burden exhibited faster weight loss (interaction p = 0.02), after adjusting for age, sex, education, and APOE4 status. Faster amyloid deposition was associated with greater weight loss (p = 0.045, r = -0.20). Subgroup analyses suggested that the relationships remained significant in female and individuals without APOE4 status.

Conclusions

Late-life weight loss was a preclinical manifestation of amyloid deposition. Elders who experienced weight loss might be targeted for primary prevention of AD.

Authors/Disclosures
Wei Xu PRESENTER	No disclosure on file

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