好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Pachymeningeal Enhancement in Anti-NMDA Receptor Encephalitis
Autoimmune Neurology
P3 - Poster Session 3 (12:00 PM-1:00 PM)
15-006
To describe the frequency and characteristics of patients with anti-NMDAR encephalitis (ANMDARE) and pachymeningeal enhancement (PE).
PE has been seldom described in ANMDARE. Due to its rarity, it is not even mentioned in the reviews on imaging features of autoimmune encephalitis (AE). Since PE usually suggests other etiologies, we must not forget that it can also be seen in ANMDARE.
As part of a prospective study (2013 onwards), patients with a clinical suspicion of AE were systematically assessed (including MRI). Patients with PE were identified and described. Only those with complete data were included in this study.

Of the total patients (n=120), 80 (66%) had anti-NMDAR antibodies in serum/CSF and were classified as ANMDARE; 6 of them (7.5%) showed PE (5 females; median age: 18.5 years, IQR: 28.5 years). MRIs were performed between 5 days and 4 months after the clinical onset. All MRIs were done after lumbar puncture (LP) (median days after LP: 3.5 [IQR: 6] days). No symptom or other imaging feature suggested intracranial hypotension. Their median CSF cell count, glucose and protein levels were 6.5 (IQR: 44.5), 68±14.8 mg/dL, and 31.5 (IQR: 319.25) mg/dL, respectively. CSF PCR panel was available in four cases and tested positive in two (EBV and CMV). In four patients the enhancement was predominantly pachymeningeal and more prominent in the convexity and over the parietal and occipital lobes. All patients received immunomodulatory therapy and, those who tested positive for virus, also acyclovir. One patient died after a protracted hospital stay; her CSF PCR panel tested negative.

In our center, PE is not so uncommon in ANMDARE. In the CSF of a third of these patients, a neurotropic DNA virus was detected during the same episode. In both cases, they were members of the Herpesviridae family.
Authors/Disclosures

PRESENTER
No disclosure on file
Jesús Ramírez-Bermúdez No disclosure on file
Jose J. Flores-Rivera, MD Dr. Flores-Rivera has nothing to disclose.
Veronica Rivas Veronica Rivas has nothing to disclose.
Jose Ignacio Munoz-Lopez No disclosure on file
No disclosure on file
Mariana Espinola-Nadurille No disclosure on file