Objective of this study is to evaluate the association between final infarct volume on MRI, anatomic correlates of the infarct and the clinical outcome in ischemic stroke. Using volumetric analysis of infracts we aim for early prediction of clinical outcomes in stroke.

A total of 21 subjects with a median age of 73 years ± 10.3 were included in the analysis. The median NIHSS at presentation was 14.3 ± 4.9. The mean volume of infarct was 28.6cc ± 29.2 95% CI: 15.4 – 42.0, and the ADC intensity was 708.0 ± 138.3 95% CI: 645.5 – 7713.

Using nonparametric spearman’s correlation, the three variables that correlated with the functional outcome at three months (mRS 0-5) were infarct volume (p=0.02), cortical (p=0.02) and left hemisphere involvement (p=0.001). In univariate analysis, the volume of infarct (p=0.07) showed a trend for association with functional outcome groups. Age-adjusted logistic regression revealed a trend between the infarct volume (p=0.06) and poor functional outcome. 

Infarct volume, cortical, and left cerebral hemispheric involvement correlate with clinical outcome. Findings of this pilot data analysis are in concordance with previously published studies on infarct volumes. Using larger patient-data from this ongoing project, models predicting 90-day clinical and functional outcomes in stroke are presented.