Abstract Details

Title Gender Differences In Etiologies Of Stroke-related Deaths In An Era Of Availability For Stroke Intervention

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P3 - Poster Session 3 (12:00 PM-1:00 PM)

Poster/Presentation
Number 4-018

Objective Are identifiable differences for causes of stroke-related death among women and men?

Background

Stroke is a disease that affects women unequally more than men. With the aging US population, stroke prevalence is projected to increase, especially among elderly females. In an era where the availability of acute stroke treatment and its early complications continue to rise, we sought to determine if there are identifiable differences for causes of stroke-related death among women and men.

Design/Methods

We used a stroke death registry following acute ischemic stroke at a single academic center from 2009 to 2017. Past medical history, in-hospital data, and cause of death was retrospectively collected from chart review. Female baseline characteristics were compared to male. Causes of deaths among females >/=65 versus <65 were compared using student’s t- and x2 tests.

Results Among all stroke deaths (n=162), there were 72 (44.4%) females, 90 (55.6%) males, with a mean age of 73 and 69, respectively. The proportion of smokers was higher among men (60.2% v 28.6%, p<0.001). Among causes of death, there was no difference seen between female and male groups for malignant edema (43.1 v 33.3%,p=0.20), index stroke (2.8 v 3.3%,p=1.00), systemic complication (27.8 v 35.6%, p=0.29), withdrawal of care (12.5 v 22.2%,p=0.11); among post-treatment hemorrhage/complications, a trend was seen towards females that did not reach statistical significance (13.9 v 5.6%,p=0.07). Of these female deaths from post-treatment complications, 6 or 60% received both IV thrombolysis (IV-tPA) and endovascular treatment (EVT), while the minority received either (30% IV-tPA, 10% EVT).

Conclusions The trend for higher rate of post-treatment complications in women deserves further study in larger datasets. Women could be at higher risk for hemorrhage following IV-tPA and EVT due to older age.

Authors/Disclosures
Alyssa Bautista, MD (Columbia University Medical Center) PRESENTER	Dr. Bautista has or had stock in Gravity Medical Technology.
Sai P. Polineni, MD	Dr. Polineni has nothing to disclose.
Seemant Chaturvedi, MD, FAHA, FAAN (University of Maryland)	Dr. Chaturvedi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Chaturvedi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Chaturvedi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Chaturvedi has received research support from NINDS.

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