Abstract Details

Title Quality of Life in Patients with Multiple Sclerosis and Those with Neuromyelitis Optica Spectrum Disorders

Topic Multiple Sclerosis

Presentation(s) MS and CNS Inflammatory Disease Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 063

Objective To evaluate and compare the quality of life (QoL) in patients with multiple sclerosis (MS) and those with neuromyelitis optica spectrum disorders (NMOSD)

Background Both MS and NMOSD affect patients during the lifetime. QoL and its associated factors in these patients are yet unknown.

Design/Methods Between June 2018 and April 2020, patients with MS and those with anti-aquaporin-4 antibody-positive NMOSD who visited a tertiary hospital were prospectively enrolled. The EuroQoL 5 Dimensions (EQ-5D) index (range: 0-1), of which low values represent poor QoL, was collected, along with Expanded Disability Status Scale (EDSS), at enrollment and at follow-up with a 6-12 months interval. At baseline, degrees of relationship between EQ-5D index and clinical factors were evaluated, adjusted by age and disease duration. We also analyzed longitudinal alteration of EQ-5D index over time.

Results During the study period, 171 patients (120 for MS, 51 for NMOSD) were included. The median age was 46 years, and median follow-up duration was 8 months. At baseline, EQ-5D index was decreased and was comparable between the MS and NMOSD groups (median: 0.86 vs. 0.82, p=0.823). In the MS group, EQ-5D index was correlated with EDSS scores (r, -0.755, p<0.001), the frequency of optic neuritis (r, -0.336, p<0.001) and transverse myelitis (r, -0.226, p=0.019). In the NMOSD group, EQ-5D index also showed a significant correlation with EDSS scores (r, -0.424, p=0.006), however did not demonstrate significant relationships with any type of clinical attacks. Longitudinally, EQ-5D scores remain decreased and did not significantly change over time in both disease groups.

Conclusions The QoL for patients with MS and NMOSD was similar in its degrees and associations with current neurologic status. Notably, specific clinical attacks were associated with QoL in MS patients, but not in NMOSD patients, which may reflect different pathogenesis and characteristics between the diseases.

Authors/Disclosures
Seungmin Kim PRESENTER	Kim Seungmin has nothing to disclose.
Eun-Jae Lee, MD, PhD (Asan Medical Center)	The institution of Prof. Lee has received research support from Republic of Korea .
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Kwang-Kuk Kim, MD (Asan Medical Center 388-1)	No disclosure on file
Young-Min Lim, MD	Dr. Lim has nothing to disclose.

��ɫ��

��ɫ��