Abstract Details

Title The Association Between Childhood Maltreatment and Pain Catastrophizing in Individuals with Multiple Sclerosis and Other Immune-mediated Inflammatory Disease

Topic Multiple Sclerosis

Presentation(s) MS and CNS Inflammatory Disease Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 119

Objective We compared frequency of pain catastrophizing in persons with multiple sclerosis (MS), other immune-mediated inflammatory diseases (IMID), and healthy controls. We assessed whether the relationship between childhood maltreatment and pain catastrophizing differs between MS and other IMID.

Background Childhood maltreatment is associated with increased risk of developing an IMID and with pain catastrophizing in adulthood. Pain catastrophizing may be more common in people with an IMID, but it is not known whether childhood maltreatment accounts for the increased risk of pain catastrophizing in individuals with MS or other IMID.

Design/Methods Individuals with MS, inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) were enrolled in a study between November 2014 and July 2016. We subsequently recruited healthy controls. Participants completed the Childhood Trauma Questionnaire-Short Form, Pain Catastrophizing Scale, and Hospital Anxiety and Depression Scale. We examined the association of childhood maltreatment and pain catastrophizing using multivariable logistic regression.

Results We included 232 individuals with MS, 215 with IBD, 130 with RA and 102 healthy controls. Individuals with MS or another IMID were more likely to report pain catastrophizing (12.3%) than healthy controls (2.0%) and were more likely to report any childhood maltreatment (45.8% vs. 27.5%). After controlling for sociodemographic factors as well as symptoms of anxiety and depression, individuals with IMID were more likely to report pain catastrophizing if they had experienced childhood maltreatment (OR 2.55; 95%CI: 1.39, 4.67). The number of healthy controls who pain catastrophized was too small to test the adjusted maltreatment-pain catastrophizing association in that group. The association between childhood maltreatment and pain catastrophizing did not differ between people with MS, IBD and RA.

Conclusions Childhood maltreatment is a risk factor for pain catastrophizing in individuals with MS and other IMID. Trauma-informed care and interventions addressing pain catastrophizing may aid management of chronic pain in MS and other IMID.

Authors/Disclosures
Tyler M. MacDonald PRESENTER	Mr. MacDonald has nothing to disclose.
John D. Fisk, PhD (Nova Scotia Health)	The institution of Dr. Fisk has received research support from Canadian Institutes of Health Research. The institution of Dr. Fisk has received research support from Multiple Sclerosis Society of Canada. Dr. Fisk has received publishing royalties from a publication relating to health care.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Scott Patten, PhD (Univ of Calgary, Community Health Sciences)	Dr. Patten has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Canadian Psychiatric Association. Dr. Patten has received publishing royalties from a publication relating to health care.
	No disclosure on file
Ruth-Ann Marrie, MD, PhD (University of Manitoba)	The institution of Dr. Marrie has received research support from CIHR. The institution of Dr. Marrie has received research support from MS Canada. The institution of Dr. Marrie has received research support from National MS Society. The institution of Dr. Marrie has received research support from Crohn's and Colitis Canada. The institution of Dr. Marrie has received research support from US Department of Defense. The institution of Dr. Marrie has received research support from The Arthritis Society. The institution of Dr. Marrie has received research support from CMSC.

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