Abstract Details

Title Evaluating Changes Produced by Progressive Resistance Training in the Metabolome of MS Patients

Topic Multiple Sclerosis

Presentation(s) MS and CNS Inflammatory Disease Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 123

Objective The goal of this study was to evaluate the effects of an exercise intervention - progressive resistance training (PRT) on the metabolome of MS patients and healthy controls and to link these changes to effects on clinical outcomes - fatigue, disability and cardiovascular fitness.

Background While the beneficial effects of exercise on MS related symptoms are known, the mechanisms by which exercise produces these pleiotropic effects are not well understood. Since exercise produces alterations in multiple metabolic pathways some of these changes may underlie the beneficial effects of exercise.

Design/Methods We recruited healthy controls and RRMS patients stable on therapy for 6 months with EDSS < 3.0, for this study of a 12-week in-person PRT intervention. Participants underwent phlebotomy at baseline and end of study in addition to evaluation of cardiovascular fitness (VO2 max), EDSS assessment, timed 25 foot walk (T25FW), six minute walk test (6MWT), hip strength measurement using dynamometry and completed modified fatigue impact scale (MFIS). Plasma was used for untargeted metabolomics analysis at Metabolon Inc.

Results 14 MS patients and 13 controls completed the exercise intervention. The PRT intervention resulted in significant improvment in hip strength, distance walked in 6WMT, speed of walking (T25FW) in both groups and in fatigue (MFIS and both subscales) in the MS group. There was a significant impact on fatty acid, phospholipid and sex steroid metabolism (p<0.05 for all) with PRT in MS. We noted a strong correlation between change in MFIS or MFIS physical sub-scale scores and change in sex steroid metabolism (r=0.65, p=0.01; r=0.64, p=0.01 respectively). We also noted a strong correlation between change in estimated VO2 max and change in fatty acid metabolism (r=0.61, p=0.03) in MS.

Conclusions Exercise intervention had significant impact on fatty acid, phospholipid and sex steroid metabolism in MS which were strongly linked to improvements in cardiovascular fitness and fatigue.

Authors/Disclosures
Pavan Bhargava, MD, FAAN (Johns Hopkins University) PRESENTER	The institution of Dr. Bhargava has received research support from EMD Serono. The institution of Dr. Bhargava has received research support from Amylyx pharmaceuticals. The institution of Dr. Bhargava has received research support from Genentech. The institution of Dr. Bhargava has received research support from GSK.
	No disclosure on file
Kathleen M. Zackowski, PhD, OTR (National MS Society)	Dr. Zackowski has received personal compensation for serving as an employee of National MS Society.

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