Abstract Details

Title Prenatal and Perinatal Factors Associated with Multiple Sclerosis Later in Life: A Systematic Review and Meta-Analysis

Topic Multiple Sclerosis

Presentation(s) MS and CNS Inflammatory Disease Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 113

Objective

In the present study we aimed to systematically review the available evidences on prenatal/perinatal factors associated with multiple sclerosis (MS) occurrence in the offspring and to conduct meta-analyses on the possible factors.

Background Exposures during early-life period are known to affect risk of developing many neurological conditions later in life. Despite the increasing prevalence of MS, no study has systematically reviewed prenatal/perinatal factors associated with MS occurrence hitherto.

Design/Methods Systematic search was performed on main electronic databases of PubMed, Web of Science, and Scopus. Original observational studies that were on human participants and evaluated the association between prenatal/perinatal factors and MS occurrence were included. Data were extracted according to the PRISMA guideline. The adjusted odds ratio (OR) with 95% confidence interval (CI) was considered as the desired effect size. The heterogeneity was evaluated by Cochran's Q and I², and the publication bias was assessed. The random-effects model was used, and sensitivity analyses were performed. The quality assessment was conducted using the Newcastle-Ottawa scale.

Results

Overall 2306 records were identified in the primary search. Excluding irrelevant studies, 34 studies contributing data on 100 prenatal/perinatal factors associated with an increased or decreased risk of MS occurrence were evaluated. In the meta-analyses, no statistically significant associations were found between prenatal smoking exposure (OR=1.01, 95% CI=0.77–1.34), mode of delivery (OR=0.90, 95% CI=0.52–1.56), birth order (OR=0.85, 95% CI=0.72–1.00), and maternal age (OR=1.34, 95% CI=0.88–2.04), and MS occurrence in the offspring.

Conclusions The current meta-analyses showed that early life factors as prenatal smoking exposure, mode of delivery, birth order, and maternal age do not affect the risk of future MS occurrence. Exposures during prenatal/perinatal periods may not be as important as future life periods in affecting MS occurrence risk, although future longitudinal studies are needed to confirm these findings.

Authors/Disclosures
Negin Badihian, MD PRESENTER	Dr. Badihian has nothing to disclose.
	No disclosure on file
Negin Badihian, MD	Dr. Badihian has nothing to disclose.
Shervin Badihian, MD (Cleveland Clinic)	Dr. Badihian has nothing to disclose.
	No disclosure on file

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