Abstract Details

Title Incidence of Creutzfeldt-Jakob Disease in the United States 1993-2014

Topic Neuroepidemiology

Presentation(s) S12 - Neuroepidemiology (2:36 PM-2:48 PM)

Poster/Presentation
Number 009

Objective To test the hypothesis that the incidence of Creutzfeldt-Jakob disease (CJD) has remained constant, we calculated the rate of hospitalizations for CJD in the United States using the National Inpatient Sample (NIS) from 2000 to 2014.

Background NA

Design/Methods We used ICD-9-CM codes to identify adults hospitalized with presumed CJD in the National Inpatient Sample (NIS) from 2000 to 2014. National Inpatient Sample survey weights were used to calculate nationally representative estimates. We used logistic regression and Jointpoint regression to evaluate the trend in the rate of hospitalizations for CJD.

Results From 2000 to 2014, we identified 8,789 admissions for CJD. Across this period, the rate of CJD-related hospitalizations increased significantly from 16 (95% CI, 12-19) to 29 (95% CI, 24-34) per million hospitalizations (OR, 1.05; 95% CI, 1.04-1.07). Joinpoint regression detected that, from 2000 to 2014, the hospitalization rate significantly increased from 1.6 (95% CI, 1.2-2.0) to 2.7 (95% CI, 2.2-3.2) per million persons (annual percentage change, 4.6%; 95% CI, 3.2%-6.0%).

Conclusions The incidence of CJD increased in the United States from 2000 to 2014.

Authors/Disclosures
Alison Seitz, MD (New York Presbyterian Hospital) PRESENTER	Dr. Seitz has stock in Colgate Palmolive.
	No disclosure on file
Alexander Merkler, MD	Dr. Merkler has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for The Neurohospitalist. Dr. Merkler has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for n/a.

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