Abstract Details

Title Association of Multiple Inflammatory Biomarkers with Cerebral Arterial Atherosclerosis and Dolichoectasia

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-003

Objective We investigated the association between multiple circulating inflammatory biomarkers and cerebral arterial atherosclerosis and dolichoectasia in a community-based sample.

Background Although dozens of biomarkers of inflammation are found to be related to vascular disease, prior studies usually have investigated the associations between arteriopathy and individual rather than multiple inflammatory factors, leaving the weights of each factor unassessed.

Design/Methods We performed a cross-sectional study including a panel of 14 inflammatory biomarkers representing systemic inflammation (high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-α), endothelial-related inflammation (intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, E-selectin, lipoprotein-associated phospholipase A2, chitinase-3-like-1 protein, and CD40 ligand), and media-related inflammation (matrix metalloproteinases-2, -3, and -9, and osteopontin) in cerebral arterial atherosclerosis and dolichoectasia in 960 stroke-free participants.

Results Intracranial atherosclerotic stenosis was observed in 15.26% (146/957); carotid plaques in 49.13% (454/924); basilar arterial dolichoectasia in 3.77 (36/955); and the average diameter of the basilar artery was 3.06±0.56 mm (955). High levels of serum endothelial-related inflammatory biomarkers were related to the presence of intracranial atherosclerotic stenosis (R2=0.215, p=0.024) and carotid plaques (R2=0.342, p=0.013). Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers showed that E-selectin was prominent (β=0.67, 95% CI 0.54-0.85, p=0.001; β=0.79, 95% CI 0.68-0.93, p=0.005). Systemic inflammatory biomarkers were associated with an increased basilar artery diameter (R2=0.051, p<0.001), and backward stepwise elimination of individual systemic-related inflammatory biomarkers showed that IL-6 was prominent (β=0.07, 95% CI 0.03-0.11, p<0.001).

Conclusions Cerebral arterial atherosclerosis and dolichoectasia are associated with different inflammatory biomarkers, suggesting different underlying inflammatory processes and mechanisms.

Authors/Disclosures
Yuan Cao (PUMCH) PRESENTER	Ms. Cao has nothing to disclose.
Ding-Ding Zhang	Ding-Ding Zhang has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Fei Han	Fei Han has nothing to disclose.
Fei-Fei Zhai	Fei-Fei Zhai has nothing to disclose.
	No disclosure on file
Jun Ni	Jun Ni has nothing to disclose.
Ming Yao	Ming Yao has nothing to disclose.
Mingli Li	No disclosure on file
Zheng-Yu Jin	No disclosure on file
Shu-Yang Zhang	No disclosure on file
Li-Ying Cui	No disclosure on file
	No disclosure on file
Yi-Cheng Zhu, MD, PhD (Peking Union Medical College Hospital)	Dr. Zhu has nothing to disclose.

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