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Abstract Details

Bilateral Disc Edema Heralding Ocular Syphilis: A Case Series
Infectious Disease
P10 - Poster Session 10 (8:00 AM-9:00 AM)
13-006
To describe five patients presenting with visual symptoms and disc edema who were diagnosed with ocular syphilis.
The Centers for Disease Control and Prevention (CDC) reported that in 2017-2021, men accounted for 83% of syphilis cases. Gay, bisexual, and other men who have sex with men account for 53% of male cases.  Human immunodeficiency virus (HIV) positivity increases a patient’s risk of developing neurosyphilis.
Case series
The mean age of patients was 49 years (range 42-57).  All were male.Three patients were positive for HIV but had undetected viral loads at the time of ocular syphilis diagnosis.  Patients presented with varying degrees of impaired visual acuity, and each had improvement of visual acuity with treatment.  RPR titers were elevated at the time of diagnosis and improved with treatment.  CSF VDRL was negative in each case.  Each patient was diagnosed with ocular syphilis and treated with 18-24 million units of intravenous aqueous crystalline penicillin daily for 10-14 days.  Response to treatment was recorded based on examination and rapid plasma reagin (RPR) titers at 3 months. 
Ocular syphilis and neurosyphilis can be seen even in immunocompetent patients.  Isolated ocular syphilis is an uncommon presentation of neurosyphilis, and may be associated with normal CSF evaluation.  In our patients, treatment had been initiated prior to sampling of CSF, which could contribute to nonreactive VDRL.  It is important to consider ocular syphilis in middle-aged male patients who present with vision loss and disc edema as it is a treatable and potentially reversible cause of vision loss.
Authors/Disclosures
Taylor R. Anderson, MD (Trinity Health Muskegon)
PRESENTER 		Dr. Anderson has nothing to disclose.
Laura Hayse, MD Ms. Hayse has nothing to disclose.
Ronel Santos (Hauenstein Neurosciences Trinity Health Grand Rapids) No disclosure on file
No disclosure on file
Aileen Antonio, MD, FAAN (Trinity Health Grand Rapids Hauenstein Neurosciences) Dr. Antonio has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Cochrane. An immediate family member of Dr. Antonio has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Giamarco, Mullins & Horton PC. The institution of Dr. Antonio has received research support from Saint Mary's Foundation. Dr. Antonio has received research support from 好色先生. Dr. Antonio has received personal compensation in the range of $0-$499 for serving as a Invited Speaker with Michigan State University.