NMO-SD is a demyelinating disorder of the CNS characterized by optic neuritis, transverse myelitis, and brainstem syndromes. Given the somewhat recent discovery of MOG, not much work is published on how this disorder manifests clinically as part of the NMO spectrum. NMO-SD is more common among non-White populations, specifically of Asian and African descent. Puerto Rico is a population with Afro-Caribbean descent, however to our knowledge there is no published data regarding this spectrum of conditions in our population.

Observational retrospective cohort study was conducted via questionnaire with NMO-SD patients. Cohorts were stratified based on seropositive status and evaluated regarding initial clinical presentation and demographic factors. Categorical and numerical data was analyzed using statistical analysis software.

A data repository describing the clinical presentation and sociodemographic characteristics of the Puerto Rican NMO-SD population was successfully compiled. Despite anticipated sample-size driven limitations common to rare diseases, clinical significance was identified in traits of the NMOSD population such as lesion location and clinical manifestation. Additional data should continue being collected to enable stronger relationships to become more apparent.

Acronyms: Neuromyelitis Optica Spectrum Disorder (NMO-SD), Central Nervous System (CNS), Myelin oligodendrocyte glycoprotein (MOG), Aquaporin 4-positive (AQP4+)