Abstract Details

Title Early Life Exposure to Pesticides and Well Water and Risk of Developing Parkinson’s Disease Later in Life

Topic Movement Disorders

Presentation(s) P8 - Poster Session 8 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-013

Objective To investigate the risk of Parkinson’s disease (PD) in relation to early life well water and agricultural settings.

Background The need to identify modifiable risk factors for PD is urgent given the failure to identify neuroprotective therapies for PD. The long prodromal disease period of PD likely indicates that early-life risk factors may be critical for understanding disease risk. Existing literature is limited when it comes to investigations of early-life exposures and their association with PD. To bridge this gap, we investigated the relationship between early-life exposures and PD risk, focusing on rural risk factors.

Design/Methods We obtained data from the Parkinson’s Environment, Diet, and Lifestyle Study which included 385 prevalent PD cases and 609 controls in the Minneapolis metro area. Early-life exposure was defined as exposure at the residence where the participant resided for the longest duration prior to reaching the age of 20. We modeled early-life exposures (well water and farm-living) in logistic regression models, adjusting for age, sex, race, and cigarette use (ever/never smoking). As a comparison analysis, we explored PD risk in relation to late-life exposure to pesticide and well water.

Results Growing up on a farm was associated with a 1.70 greater risk of PD (95% CI 1.26-2.29). Early-life exposure to well water as a primary drinking source was associated with a 1.61 greater risk of developing PD (95% CI 1.18-2.20). We found no significant association between our late-life exposure to farm-living (OR 1.43, 95% CI 0.79-2.63) and well water (OR 1.95, 95% CI 0.97-3.94).

Conclusions

Exposures to well water and farm-living might increase risk of developing PD. Future work should focus on early-life exposures and attempt to pinpoint the critical period of exposure to better understand PD risk factors.

Authors/Disclosures
Jenna K. Moses PRESENTER	Miss Moses has nothing to disclose.
Susan Criswell, MD (Washington University)	Dr. Criswell has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie.
Brad A. Racette, MD, FAAN (Barrow Neurological Institute)	Dr. Racette has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for American Regent. Dr. Racette has received personal compensation in the range of $500-$4,999 for serving as a advisory council with NIEHS.
Brittany Krzyzanowski, PhD	Dr. Krzyzanowski has nothing to disclose.

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