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2026 Annual Meeting | PL6 - Contemporary Clinical Issues Plenary Session

Wednesday 04/22/26
09:15 AM - 11:00 AM CDT Add To Calendar
This program will be presented both in-person and online
This program will be available in the meeting's On Demand product.
Plenary Session
Chad Hales, MD, PhD, FAAN
General Neurology, Movement Disorders, Practice, Policy, and Ethics, Aging, Dementia, and Behavioral Neurology, Multiple Sclerosis
This session highlights issues most critical to practicing neurologists, including abstracts related to new therapeutic developments, clinical applications of basic and translational research, and innovative technical developments already affecting the practice of neurology.
1.75 CME credits
Artificial Intelligence
Event Timeline
09:15 AM - 09:25 AM CDT Speaker Presenter: AMT-130 Huntington’s Disease Gene Therapy: Clinical Study Outcomes at 3 Years
Victor W. Sung, MD
09:25 AM - 09:35 AM CDT Speaker Discussant: AMT-130 Huntington’s Disease Gene Therapy: Clinical Study Outcomes at 3 Years
Yvette Bordelon, MD, PhD, FAAN
09:35 AM - 09:45 AM CDT Speaker Presenter: Bridging the Knowledge Gap: Real-world Implementation of an AI Clinical Assistant in Neurology
Mikael Guzman Karlsson, MD, PhD
09:45 AM - 09:55 AM CDT Speaker Disussant: Bridging the Knowledge Gap: Real-world Implementation of an AI Clinical Assistant in Neurology
Lidia Maria V. Moura, MD, PhD, MPH, FAAN
09:55 AM - 10:05 AM CDT Speaker Presenter: Efficacy and Safety of Tolebrutinib Versus Placebo in Primary Progressive Multiple Sclerosis: Results from the Phase 3 PERSEUS Trial
Robert J. Fox, MD, FAAN
10:05 AM - 10:15 AM CDT Speaker Discussant: Efficacy and Safety of Tolebrutinib Versus Placebo in Primary Progressive Multiple Sclerosis: Results from the Phase 3 PERSEUS Trial
Farrah J. Mateen, MD, PhD, FAAN
10:15 AM - 10:25 AM CDT Speaker Presenter: Lifestyle Interventions vs. Monoclonal Antibodies in Mild Cognitive Impairment and Early Alzheimer’s Disease: A Comparative Review of Randomized Controlled Trials
Majid Fotuhi, MD, PhD
10:25 AM - 10:35 AM CDT Speaker Discussant: Lifestyle Interventions vs. Monoclonal Antibodies in Mild Cognitive Impairment and Early Alzheimer’s Disease: A Comparative Review of Randomized Controlled Trials
Neelum T. Aggarwal, MD
10:35 AM - 10:45 AM CDT Speaker Presenter: Enhancing Glymphatic Transport via Vasopressin: Implications of Neurodegenerative Disease and Drug Delivery
Eman Hamed, MD, PhD
10:45 AM - 10:55 AM CDT Speaker Discussant: Enhancing Glymphatic Transport via Vasopressin: Implications of Neurodegenerative Disease and Drug Delivery
Humberto Mestre, MD, PhD
Faculty Disclosures
Chad Hales, MD, PhD, FAAN The institution of Dr. Hales has received research support from BrightFocus foundation. The institution of Dr. Hales has received research support from NIH. The institution of Dr. Hales has received research support from State of Georgia. Dr. Hales has a non-compensated relationship as a committee member with AAN that is relevant to AAN interests or activities.
Robert J. Fox, MD, FAAN Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AB Science. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BMS. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Fox has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Immunic. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Fox has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as a Consultant for TG Therapeutics. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astoria Biologica. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as a Consultant for InnoCare Pharma. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Immunic. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AB Science. Dr. Fox has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Fox has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS. The institution of Dr. Fox has received research support from National Institutes of Health. The institution of Dr. Fox has received research support from National MS Society. Dr. Fox has received publishing royalties from a publication relating to health care.
Majid Fotuhi, MD, PhD Dr. Fotuhi has nothing to disclose.
Lidia Maria V. Moura, MD, PhD, MPH, FAAN Dr. Moura has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Moura has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. The institution of Dr. Moura has received research support from Centers for Diseases Control and Prevention (CDC SIP20-007) . The institution of Dr. Moura has received research support from Epilepsy Foundation of America . The institution of Dr. Moura has received research support from NIH - NIA and NINDS. Dr. Moura has received personal compensation in the range of $50,000-$99,999 for serving as a Expert Advisor with Epilepsy Foundation .
Victor W. Sung, MD Dr. Sung has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Teva Neuroscience. Dr. Sung has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Sung has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Neurocrine. Dr. Sung has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UniQure.
Mikael Guzman Karlsson, MD, PhD An immediate family member of Dr. Guzman Karlsson has received personal compensation for serving as an employee of Ventyx Biosciences, Inc..
Eman Hamed, MD, PhD Dr. Hamed has nothing to disclose.
Farrah J. Mateen, MD, PhD, FAAN Dr. Mateen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Mateen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Mateen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Dr. Mateen has received research support from Genentech. The institution of Dr. Mateen has received research support from Amgen. The institution of Dr. Mateen has received research support from TG Therapeutics. Dr. Mateen has received intellectual property interests from a discovery or technology relating to health care.
Humberto Mestre, MD, PhD The institution of Dr. Mestre has received research support from Brain Aneurysm Foundation. The institution of Dr. Mestre has received research support from National Institute of Health. Dr. Mestre has received intellectual property interests from a discovery or technology relating to health care.
Neelum T. Aggarwal, MD Dr. Aggarwal has received personal compensation in the range of $500-$4,999 for serving as a Consultant with AtWHealth . Dr. Aggarwal has received personal compensation in the range of $500-$4,999 for serving as a Speaker with VCU Health.
Yvette Bordelon, MD, PhD, FAAN Dr. Bordelon has nothing to disclose.