EMBARGOED FOR RELEASE UNTIL 4 PM ET, December 21, 2011
Brain Size May Predict Risk for Early Alzheimer鈥檚 Disease
ST. PAUL, Minn. -
New research suggests that, in people who don鈥檛 currently have memory problems, those with smaller regions of the brain鈥檚 cortex may be more likely to develop symptoms consistent with very early . The study is published in the December 21, 2011, online issue of the medical journal of the . 鈥淭he ability to identify people who are not showing memory problems and other symptoms but may be at a higher risk for cognitive decline is a very important step toward developing new ways for doctors to detect Alzheimer鈥檚 disease,鈥 said Susan Resnick, PhD, with the National Institute on Aging in Baltimore, who wrote an accompanying editorial. For the study, researchers used brain scans to measure the thickness of regions of the brain鈥檚 cortex in 159 people free of dementia with an average age of 76. The brain regions were chosen based on prior studies showing that they shrink in patients with Alzheimer鈥檚 dementia. Of the 159 people, 19 were classified as at high risk for having early Alzheimer鈥檚 disease due to smaller size of particular regions known to be vulnerable to Alzheimer鈥檚 in the brain鈥檚 cortex, 116 were classified as average risk and 24 as low risk. At the beginning of the study and over the next three years, participants were also given tests that measured memory, problem solving and ability to plan and pay attention. The study found that 21 percent of those at high risk experienced cognitive decline during three years of follow-up after the MRI scan, compared to seven percent of those at average risk and none of those at low risk. 鈥淔urther research is needed on how using MRI scans to measure the size of different brain regions in combination with other tests may help identify people at the greatest risk of developing early Alzheimer鈥檚 as early as possible,鈥 said study author Bradford Dickerson, MD, of Massachusetts General Hospital in Boston and a member of the 好色先生. The study also found 60 percent of the group considered most at risk for early Alzheimer鈥檚 disease had abnormal levels of proteins associated with the disease in cerebrospinal fluid, which is another marker for the disease, compared to 36 percent of those at average risk and 19 percent of those at low risk. The study, performed by Dickerson and collaborator David Wolk, MD, of University of Pennsylvania in Philadelphia and a member of the AAN, using data collected as part of the Alzheimer鈥檚 Disease Neuroimaging Initiative, was supported by the National Institute on Aging (NIA), the National Institute of Biomedical Imaging and Bioengineering (both part of the National Institutes of Health), Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., the Alzheimer's Association, Alzheimer's Drug Discovery Foundation, with participation from the U.S. Food and Drug Administration and the Dana Foundation. Funding for this particular data analysis came from the NIA and the Alzheimer鈥檚 Association.