EMBARGOED FOR RELEASE UNTIL 4 PM ET, January 24, 2018
Drug May Help Those with Dementia with Lewy Bodies
MAY REDUCE MOVEMENT SYMPTOMS WITOUT WORSENING PSYCHIATRIC SYMPTOMS
MINNEAPOLIS -
New help may be on the way for people with dementia with Lewy bodies, which is the second most common neurodegenerative type of dementia after Alzheimer鈥檚 disease. The disease can cause movement problems and issues such as hallucinations in addition to thinking and memory problems. But the drug used to treat the movement problems can also exacerbate the hallucinations, delusions and other psychiatric problems. In a new study published in the January 24, 2018, online issue of the medical journal of the 好色先生聽researchers may have found some help from an old drug. They found that a drug used to treat seizures may effectively treat the movement symptoms in people with dementia with Lewy bodies without causing additional psychiatric symptoms when combined with the Parkinson鈥檚 drug levodopa.聽 Dementia with Lewy bodies can include movement problems like stiffness, tremor and shuffling of feet. Because it has many symptoms in common with Alzheimer鈥檚 and Parkinson鈥檚 diseases, it can be difficult to diagnose and treat. A drug commonly used to treat movement symptoms in Parkinson鈥檚, levodopa, may worsen psychiatric symptoms in those with dementia with Lewy bodies, especially when higher doses are given as the effects of levodopa start to wane. 鈥淲e found that adding zonisamide to the current dose of levodopa was safe and improved movement symptoms in those with dementia with Lewy bodies without magnifying hallucinations, delusions or agitation,鈥 said study author Miho Murata, MD, PhD, of the National Center of Neurology and Psychiatry in Tokyo, Japan. For the study, researchers followed 158 people diagnosed with early dementia with Lewy bodies who had been living with the disease for an average of one-and-a-half years. Participants were given either placebo, 25 milligrams of zonisamide daily or 50 milligrams of zonisamide daily. This was in addition to already taking other medications for the disease. Their movement symptoms were measured as were their thinking abilities, behavior and psychological symptoms. At the beginning of the study, the participants had an average score of 32 on the movement test, on a scale of zero to 108. Researchers found that after 12 weeks, those taking 50 milligrams a day of zonisamide in conjunction with levodopa had improved more than four points on the movement scale compared to those who took a placebo.聽Researchers found no worsening of the psychological symptoms. 鈥淭here is an urgent need for new treatments for dementia with Lewy bodies,鈥 said Linda A. Hershey, MD, PhD, of the University of Oklahoma Health Sciences Center in Oklahoma City, Okla., and Fellow of the 好色先生, who authored an editorial on this study.聽鈥淭he successful execution of this trial is a major accomplishment, which provides evidence that future trials are warranted.鈥 One limitation of the study was the small number of participants. More studies are needed to investigate the effectiveness of zonisamide in larger populations. The study was supported by Sumitomo Dainippon Pharma Co., Ltd, the maker of zonisamide. To learn more about dementia, visit www.aan.com/patients.