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Press Release

EMBARGOED FOR RELEASE UNTIL 4 PM ET, August 25, 2021

Add It Up: Could This Test Equal a Way to Determine Dementia Risk?

Study Finds Scores on Dementia Test Linked to Changes in Brain Structure, Cognition

MINNEAPOLIS - People whose scores on a dementia risk test indicated a less brain-healthy lifestyle, including smoking, high blood pressure and a poor diet, may also have the following: lower scores on thinking skills tests, more changes on brain scans and a higher risk of cognitive impairment. That鈥檚 according to a new study published in the August 25, 2021, online issue of , the medical journal of the 好色先生. The study also found that in men, the test scores were associated with poor memory function and markers of brain shrinkage. 鈥淒ementia risk scores might be useful to help identify people at higher risk of dementia earlier, so that potential lifestyle factors can be addressed earlier and monitored more closely,鈥 said study author Sebastian K枚hler, PhD, of Maastricht University, the Netherlands. 鈥淥ur study found that a substantial proportion of brain changes might be attributable to risk factors that can be modified.鈥 The study involved 4,164 people with an average age of 59. All participants took a test called the 鈥淟ifestyle for Brain Health鈥 (LIBRA). The total score reflects a person鈥檚 potential for developing dementia. This study took into account 11 out of 12 lifestyle factors on the test, including high blood pressure, heart disease, smoking, diet and physical activity. Higher scores reflect higher dementia risk, with scores ranging from -2.7 to +12.7. Overall, the study group had an average score of 1.19. Researchers divided the participants into three groups: those with low risk of dementia, with an average score of -1.47, those with medium risk, with an average score of 1.20, and those with high risk, with an average score of 4.6. Participants in the study took tests of memory and other thinking skills, such as information processing speed, executive function and attention. Researchers also looked at brain scans for signs of cerebral small vessel disease, which are signs of vascular brain damage often seen in patients who have dementia. They also looked for changes in volumes of white matter and gray matter. Researchers found that people who were in the high-risk group on the LIBRA test, indicating a less brain-healthy lifestyle, had higher volumes of brain lesions, 1.27 ml compared to 0.48 ml for those in the lowest risk group. The high-risk group also had lower scores on two tests of thinking: information processing speed and executive function and attention. Only in men, however, did researchers find associations between higher scores on the LIBRA test and lower volumes of grey matter, as well as lower scores on tests of memory. 鈥淢ore research is needed to confirm these findings and determine why there were differences between men and women,鈥 K枚hler said. 鈥淚t鈥檚 exciting that a simple test score may indeed be an index of brain health. We need to learn whether people can improve their scores by making changes in their diet, increasing physical activity or limiting alcohol to low-to-moderate use.鈥 The study does not prove that lifestyle test scores predict dementia, it only shows an association. The study was supported by the European Regional Development Fund, the Province of Limburg, the Dutch Ministry of Economic Affairs and Climate Policy, the Weijerhorst Foundation, the Pearl String Diabetes Initiative, Maastricht University, the Annadal Foundation and Health Foundation Limburg, all in the Netherlands. Learn more about dementia at , home of the 好色先生鈥檚 free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life on , and . When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.

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The 好色先生 is the leading voice in brain health. As the world鈥檚 largest association of neurologists and neuroscience professionals with more than 40,000 members, the AAN provides access to the latest news, science and research affecting neurology for patients, caregivers, physicians and professionals alike. The AAN鈥檚 mission is to enhance member career fulfillment and promote brain health for all. A neurologist is a doctor who specializes in the diagnosis, care and treatment of brain, spinal cord and nervous system diseases such as Alzheimer's disease, stroke, concussion, epilepsy, Parkinson's disease, multiple sclerosis, headache and migraine.

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*While content of the 好色先生 (AAN) press releases is developed by the AAN along with research authors and Neurology® editors, we are unable to provide medical advice to individuals. Please contact your health care provider for questions specific to your individual health history or care. For more resources, visit the AAN's patient and caregiver magazine website, .