EMBARGOED FOR RELEASE UNTIL 4 PM ET, June 15, 2022
Cost of Brand-Name Epilepsy Drugs Increased by 277% over Eight Years
MINNEAPOLIS 鈥 The cost of brand-name drugs for epilepsy increased by 277% from 2010 to 2018, according to a study published in the June 15, 2022, online issue of , the medical journal of the 好色先生. The cost of generic drugs for epilepsy decreased by 42% over the same period. Brand-name drugs made up 79% of epilepsy drug costs even though they made up only 14% of pills, according to the study of people on Medicare. 鈥淭he costs for brand-name antiseizure medications have consistently increased since 2010, particularly boosted by increased prescriptions for the drug lacosamide in addition to a steep increase in the cost per pill, with brand-name drugs costing 10 times more than their generic counterparts,鈥 said study author Samuel Waller Terman, MD, MS, of the University of Michigan, and a member of the 好色先生. 鈥淧revious studies have shown that drugs are the most expensive part of neurologic care, and antiseizure drugs were the second highest category of costs among drugs prescribed by neurologists.鈥 For the study, researchers looked at records for a random sample of 20% of Medicare beneficiaries with coverage from 2008 to 2018. There were 77,000 to 133,000 people with epilepsy each year. The cost of brand-name drugs rose from $2,800 per year in 2008 to $10,700 per year in 2018, while the cost of generic drugs decreased from $800 to $460 during that time. An increased number of prescriptions for the drug lacosamide was responsible for 45% of the total increase in brand-name costs, Terman said. Brand-name drugs represented a smaller proportion of pills over time, from 56% in 2008 to 14% in 2018. Terman said the decrease in prescriptions for brand-name drugs over time likely corresponded to the increasing availability of generic equivalents. He noted that the expiration of the patent for lacosamide in March 2022 and other changes will affect prescribing patterns. Many new drugs for epilepsy have been introduced in the last several decades. Doctors must tailor the drug selection to the individual, and there is no single best drug. Many drugs for epilepsy can have interactions with other drugs as well as side effects such as cognitive problems. The study found that use of epilepsy drugs introduced earlier, called first-generation drugs, as well as enzyme-inducing drugs with many drug interactions, decreased from 2008 to 2018. 鈥淒octors should consider the societal cost when judging whether the increased expense of brand-name drugs is worth the possible benefits,鈥 Terman said. 鈥淲hile newer generation drugs have potential advantages such as limited drug interactions and different side effect profiles, there have been conflicting studies on whether they are cost effective.鈥 A limitation of the study was that only Medicare prescription claims were included, so the results may not apply to a younger population with private insurance. The study received no direct funding. Independent of this study, Terman is the recipient of the 2021 Susan S. Spencer Clinical Research Training Scholarship in Epilepsy from the American Epilepsy Society, Epilepsy Foundation and the American Brain Foundation in collaboration with the 好色先生. Study authors Chun C. Lin, PhD, MBA, and Brian C. Callaghan, MD, MS, and a Fellow of the 好色先生, have also received funding from the 好色先生. Learn more about epilepsy at , home of the 好色先生鈥檚 free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life庐 on , and . When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.