EMBARGOED FOR RELEASE UNTIL 4 PM ET, February 20, 2023
Can the Lingering Effects of a Mild Case of COVID-19 Change Your Brain?
Study Finds Brain Changes in People with Anxiety, Depression Symptoms
MINNEAPOLIS 鈥 People with long COVID who experience anxiety and depression months after a mild case of COVID-19 may have brain changes that affect the function and structure of the brain, according to a preliminary study released today, February 20, 2023, that will be presented at the 好色先生's 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023. 鈥淭here is still much to learn about long COVID, which includes a wide range of health problems, including anxiety and depression, months after infection,鈥 said Clarissa Yasuda, MD, PhD, of the University of Campinas in S茫o Paulo, Brazil. 鈥淥ur findings are concerning, as even people with a mild case of COVID-19 are showing changes in their brains months later. More studies are needed to hopefully identify treatments to prevent any long-term effects on people鈥檚 quality of life.鈥 The study involved 254 people with an average age of 41 who had a mild COVID-19 infection an average of three months earlier. Participants completed tests to assess symptoms of depression and anxiety. A total of 102 people had symptoms of both anxiety and depression and 152 people had no symptoms. Participants also had brain scans. Researchers looked at damage to the brain鈥檚 gray matter to determine if there was brain shrinkage. They also compared the brain scans of the people with COVID-19 with the scans of 148 people who did not have a COVID-19 infection. The people with COVID-19 and anxiety and depression had shrinkage in the limbic area of the brain, which plays a role in memory and emotional processing, while the people who had COVID-19 without anxiety and depression and the people without COVID-19 had no brain shrinkage. Researchers also looked at brain function and changes in connectivity鈥攈ow the brain communicates鈥攂etween areas of the brain. Using a special type of software to analyze brain networks with resting-state brain activity, they looked at 84 people from the asymptomatic group, 70 people from the anxiety and depression group, and 90 people who did not have COVID-19. Researchers found that the group with both symptoms of anxiety and depression had widespread functional changes in each of the 12 networks that were tested, while the group without symptoms showed changes in only five networks. 鈥淥ur results suggest a severe pattern of changes in how the brain communicates as well as its structure, mainly in people with anxiety and depression with long COVID syndrome, which affects so many people,鈥 Yasuda added. 鈥淭he magnitude of these changes suggests that they could lead to problems with memory and thinking skills, so we need to be exploring holistic treatments even for people mildly affected by COVID-19.鈥 A limitation of the study was that symptoms of anxiety and depression were self-reported, so people may have misjudged or misreported symptoms. The study was supported by the S茫o Paulo Research Foundation. Learn more about brain health at , home of the 好色先生鈥檚 free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life庐 on , and . When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.
