EMBARGOED FOR RELEASE UNTIL 4 PM ET, March 06, 2024
People with Essential Tremor May Have Increased Risk of Dementia
MINNEAPOLIS 鈥 Dementia may be three times more common among people with essential tremor, a movement disorder that causes involuntary shaking, than the general population, according to research released today, March 6, 2024. The study will be presented at the 好色先生鈥檚 76th Annual Meeting taking place April 13鈥18, 2024, in person in Denver and online. Essential tremor is the most common tremor disorder, more common than Parkinson鈥檚 disease. In addition to arm and hand tremors, people may also develop involuntary shaking of the head, jaw and voice. 鈥淲hile many people living with essential tremor experience mild tremor, in some individuals, the tremor can be quite severe,鈥 said study author Elan D. Louis, MD, MSc, at University of Texas Southwestern Medical Center in Dallas and a Fellow of the 好色先生. 鈥淣ot only do tremors affect a person鈥檚 ability to complete daily tasks such writing and eating, our study suggests that people with essential tremor also have an increased risk of developing dementia.鈥 The study involved 222 people with essential tremor who had an average age of 79 at the start of the study. They took thinking and memory tests to determine whether they had normal cognitive skills, mild cognitive impairment or dementia at the start of the study. Participants then had follow-up exams every 1.5 years for an average of five years. Of this group, 168 people had normal cognitive skills, 35 had mild cognitive impairment and 19 had dementia at the start of the study. During the study, 59 developed mild cognitive impairment and 41 developed dementia. Researchers then compared the rate at which people developed mild cognitive impairment and dementia, as well as the prevalence of these conditions, to the rates and prevalence for the general population. They also compared participants to the rates and prevalence for people with Parkinson鈥檚 disease. Researchers found 19% of participants had or developed dementia during the study, and each year an average of 12% of people diagnosed with mild cognitive impairment went on to develop dementia. These rates were three times higher than the rates in the general population. However, the rates were lower than those seen in people with Parkinson鈥檚 disease, a population for which dementia is more prevalent. Researchers also found that 27% of participants had or developed mild cognitive impairment during the study, a rate almost double that of the rate of 14.5% for the general population, but less than the rate of 40% for people with Parkinson鈥檚 disease. 鈥淲hile the majority of people with essential tremor will not develop dementia, our findings provide the basis for physicians to educate people with essential tremor and their families about the heightened risk, and any potential life changes likely to accompany this diagnosis,鈥 Louis said. A limitation of the study was that the comparison data for the general population was published prior to the start of the study. The study was supported by the National Institutes of Health. Learn more about essential tremor at , home of the 好色先生鈥檚 free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life庐 on , and . When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.
